Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. [PDF]
Exposure to high levels of ionizing radiation (IR) leads to debilitating and dose-limiting gastrointestinal (GI) toxicity. Using three-dimensional mouse crypt culture, we demonstrated that p53 target PUMA mediates radiation-induced apoptosis via a cell ...
Cramer, Julie M +14 more
core +2 more sources
His+ reversions Caused in Salmonella typhimurium by different types of ionizing radiation [PDF]
The yield of his+ reversions in the Ames Salmonella tester strain TA2638 has been determined for 60Co γ rays, 140 kV X rays, 5.4 keV characteristic X rays, 2.2 MeV protons, 3.1 MeV α particles, and 18 MeV/U Fe ions.
Fitzek, M. +3 more
core +1 more source
Patterns of CT lung injury and toxicity after stereotactic radiotherapy delivered with helical tomotherapy in early stage medically inoperable NSCLC [PDF]
To evaluate toxicity and patterns of radiologic lung injury on CT images after hypofractionated image-guided stereotactic body radiotherapy (SBRT) delivered with helical tomotherapy (HT) in medically early stage inoperable non-small-cell lung cancer ...
Agolli, Linda +9 more
core +1 more source
Effects of Internal Exposure of Radioactive 56MnO2 Particles on the Lung in C57BL Mice
The investigation of the radiation effects of the atomic bombing in Hiroshima and Nagasaki has revealed concerns about the impact of the residual radioactive dust produced in the soil.
Zhaslan Abishev +11 more
doaj +1 more source
Compound Kushen Injection Protects Skin From Radiation Injury via Regulating Bim
Background: Radiation-induced skin injury is a major side-effect observed in cancer patients who received radiotherapy. Thus identifying new radioprotective drugs for prevention or treatment of post-irradiation skin injury should be prompted.
Jianxiao Zheng +12 more
doaj +1 more source
Routine repeat head CT may not be necessary for patients with mild TBI. [PDF]
Background:Routine repeat cranial CT (RHCT) is standard of care for CT-verified traumatic brain injury (TBI). Despite mixed evidence, those with mild TBI are subject to radiation and expense from serial CT scans.
Deane, Molly R +4 more
core +2 more sources
Hearing Loss in Patients with Nasopharyngeal Carcinoma after Chemotherapy and Radiation
In light of the possible adverse effects of radiation on hearing, we conducted a study to evaluate the long-term sensorineural hearing status following radiotherapy (RT) in patients suffering from nasopharyngeal carcinoma.
Ling-Feng Wang +4 more
doaj +1 more source
Macrophages in radiation injury: a new therapeutic target
Radiotherapy can induce toxicity in healthy tissues such as radiation-induced fibrosis (RIF), and macrophages are proposed as new profibrogenic cells. In this Point-of-View, we summarize the role of the immune response in ionizing radiation injury, and ...
Lydia Meziani +2 more
doaj +1 more source
Salen Mn Complexes Mitigate Radiation Injury in Normal Tissues [PDF]
Salen Mn complexes, including EUK-134, EUK-189 and a newer cyclized analog EUK-207, are synthetic SOD/catalase mimetics that have beneficial effects in many models of oxidative stress.
Doctrow, Susan R. +11 more
core +2 more sources
Parent‐to‐Child Information Disclosure in Pediatric Oncology
ABSTRACT Background Despite professional consensus regarding the importance of open communication with pediatric cancer patients about their disease, actual practice patterns of disclosure are understudied. Extant literature suggests a significant proportion of children are not told about their diagnosis/prognosis, which is purported to negatively ...
Rachel A. Kentor +12 more
wiley +1 more source

