Results 71 to 80 of about 3,894,991 (398)

Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects

Antioxidants, 2023
Tocotrienols have powerful radioprotective properties in multiple organ systems and are promising candidates for development as clinically effective radiation countermeasures.
Stephen A. Shrum, Ujwani Nukala, Shivangi Shrimali, Edith Nathalie Pineda, Kimberly J. Krager, Shraddha Thakkar, Darin E. Jones, Rupak Pathak, Philip J. Breen, Nukhet Aykin-Burns, Cesar M. Compadre   +10 more
doaj   +1 more source

Loss of beta-catenin triggers oxidative stress and impairs hematopoietic regeneration [PDF]

, 2014
Accidental or deliberate ionizing radiation exposure can be fatal due to widespread hematopoietic destruction. However, little is known about either the course of injury or the molecular pathways that regulate the subsequent regenerative response.
C. Jiang, C. Zhao, J. R. Harris, K. Owzar, N. Chao, RACIOPPI, LUIGI, S. Piryani, T. Ito, T. Reya, W. Huang, W. Lento   +10 more
core   +1 more source

Dysbiosis of Gut Microbiota Is Associated With the Progression of Radiation-Induced Intestinal Injury and Is Alleviated by Oral Compound Probiotics in Mouse Model

Frontiers in Cellular and Infection Microbiology, 2021
The acute radiation-induced intestinal injury (RIII) has raised much concerns and is influenced by non-cytocidal radiation effects including the perturbations in gut microbiota.
T. Zhao, L. Xie, S. Cai, Jia-Yu Xu, Hao Zhou, Lingmao Tang, Chaofei Yang, Shuguang Fang, Ming Li, Ye Tian   +9 more
semanticscholar   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Radiation-induced liver injury and hepatocyte senescence

Cell Death Discovery, 2021
Radiation-induced liver injury (RILI) is a major complication of radiotherapy during treatment for liver cancer and other upper abdominal malignant tumors that has poor pharmacological therapeutic options.
Wei Zhu, Xiaofen Zhang, Mengli Yu, Bingru Lin, Chaohui Yu   +4 more
semanticscholar   +1 more source

Protective effects of a Chinese medicinal formula on the spleen of irradiated mice

Fushe yanjiu yu fushe gongyi xuebao, 2023
A Chinese medicinal formula was prepared by combining extracts from Astragalus, Siberian ginseng, wild Yam, grape seed, and wild Jujube and assessed for the protective effect of the Fangfu formula powder on the spleen of radiation-injured mice.
ZHOU Xi, TANG Ying, SUN Huan, CHEN Xuejiao   +3 more
doaj   +1 more source

The Effect of High Dose Total Body Irradiation on ACTH, Corticosterone, and Catecholamines in the Rat [PDF]

, 2011
Total body irradiation (TBI) or partial body irradiation is a distinct risk of accidental, wartime, or terrorist events. Total body irradiation is also used as conditioning therapy before hematopoietic stem cell transplantation.
Bruder, Eric D., Cohen, Eric P., Cullinan, William E, Raff, Hershel, Ziegler, Dana R.   +4 more
core   +2 more sources

Novel Biologically Active Glass Fiber Functionalized Using Magnesium Phosphate Cement Promotes Bone and Vascular Regeneration

Advanced Biology, EarlyView.
In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu, Yanbo Shan, Yingjie Xiong, Jianting Ye, Yanbin Wu, Jipeng Song, Yao Zhang, Wancheng Lin, Haoye Meng, Wenjing Xu, Jiang Peng, Qiang Lu, Lixiang Ding   +12 more
wiley   +1 more source

Causation’s Nuclear Future: Applying Proportional Liability to the Price-Anderson Act [PDF]

, 2014
For more than a quarter century, public discourse has pushed the nuclear-power industry in the direction of heavier regulation and greater scrutiny, effectively halting construction of new reactors.
O’Connell, William D.
core   +1 more source

Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. [PDF]

, 2015
Exposure to high levels of ionizing radiation (IR) leads to debilitating and dose-limiting gastrointestinal (GI) toxicity. Using three-dimensional mouse crypt culture, we demonstrated that p53 target PUMA mediates radiation-induced apoptosis via a cell ...
Cramer, Julie M, Dunn, James CY, Epperly, Michael, Greenberger, Joel, Judge, Colleen, Lagasse, Eric, Leibowitz, Brian J, Li, Linheng, Martin, Martin G, Stelzner, Matthias G, Wang, Fengchao, Wang, Xinwei, Wei, Liang, Yu, Jian, Zhang, Lin   +14 more
core   +2 more sources