Results 41 to 50 of about 3,787,884 (311)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Evaluation of Cardiotoxicity in HER-2-Positive Breast Cancer Patients Treated With Radiation Therapy and Trastuzumab [PDF]

, 2021
PURPOSE/OBJECTIVE(S): Trastuzumab is associated with cardiac dysfunction in HER-2 positive breast cancer patients. The current study examines the effect of radiation therapy on cardiotoxicity in this patient population.
Bachir Bachir, Jaoude, Joseph Abi, Sirine Anouti, Bachir, Bachir, Bachir, Bassel, Zeidan, Y.H., Philip Poortmans, Youssef H. Zeidan, Tfayli, Arafat Hussein, Joseph Abi Jaoude, Tfayli, Arafat, Poortmans, Philip M.P., Poortmans, Philipp, Arafat Tfayli, Majd Kayali, Evandro de Azambuja, Poortmans, Philip, Anouti, Sirine, Kayali, Majd, Abi Jaoude, Joseph, de Azambuja, Evandro, Zeidan, Youssef H.   +21 more
core   +1 more source

РАЗВИТИЕ ТЕХНОЛОГИИ РАДИАЦИОННОГО МОНИТОРИНГА В ГОРОДСКОЙ СРЕДЕ

Vestnik KRAUNC: Fiziko-Matematičeskie Nauki, 2015
В работе изложены и проанализированы результаты мониторинга метеорологических и радиационных величин в Томской обсерватории радиоактивности и ионизирующих излучений.
В.С. Яковлева, П.М. Нагорский, V.S. Yakovleva, P.M. Nagorskiy   +3 more
doaj   +1 more source

Analysis of dynamics of summary surface β-activity of deposited dust and atmospheric precipitations in the sanitary-safety zone of the WWR-M reactor of INR of the NAS of Ukraine during 2014 - 2018

Ядерна фізика та енергетика, 2020
The results of radiation monitoring of the air environment in the sanitary-protective zone of WWR-M research reactor of the Institute for Nuclear Research of the National Academy of Sciences of Ukraine for the period of 2014 - 2018 are presented.
I. O. Pavlenko, O. V. Svarychevska, A. D. Sajenyuk, O. V. Svyatun, S. V. Teletska   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Dosimetric Application of Phosphorus Doped Fibre for X-ray and Proton Therapy

Sensors, 2021
Phosphorous-doped silica optical fibres with a core diameter of 4 µm were tested in X-ray and proton fields for application in cancer therapy dosimetry.
Olugbenga J. Olusoji, Crystal Penner, Camille Bélanger-Champagne, Wern Kam, Michael Martyn, Peter Woulfe, Cornelia Hoehr, Sinead O’Keeffe   +7 more
doaj   +1 more source

The LISA Pathfinder DMU and Radiation Monitor [PDF]

Classical and Quantum Gravity, 2011
The LISA PathFinder DMU (Data Management Unit) flight model was formally accepted by ESA and ASD on 11 February 2010, after all hardware and software tests had been successfully completed. The diagnostics items are scheduled to be delivered by the end of 2010.
P. Canizares, M. Chmeissani, A. Conchillo, M. Diaz Aguillo, E. Garcia Berro, L. Gesa, F. Gilbert, GRIMANI, CATIA, I. Lloro, A. Lobo, I. Mateos, M. Nofrarias, J. Ramos Castro, J. Sanjuan, Carlos F. Sopuerta, H. M. Araujo, P. Wass   +16 more
openaire   +6 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Investigation of distribution pattern of natural radioactivity in the sediments of Jampore beach, Daman, India

Discover Oceans
In the present study, the spatial distribution of radioactivity measured both in-situ and laboratory gamma spectrometry methods has been discussed. The grain size distribution of the samples was carried out by sieving method followed by measuring the ...
Jayashree Biswal, Sunil Goswami, V. B. Yadav, S. J. Sartandel, J. S. Samantray, V. Pulhani, V. K. Sharma   +6 more
doaj   +1 more source