Results 241 to 250 of about 513,484 (358)

Long Non‐Coding RNA IGFRIL Couples with PTBP1 to Destabilize IGFBP3 mRNA to Promote the IGF1R‐AKT‐mTOR Axis and Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
The limited understanding of IGFR pathway activation hinders its clinical application in HCC. Here, IGFRIL is identified as a novel non‐coding activator of the IGF1R, which recruits PTBP1 to destabilize IGFBP3 mRNA and activates IGF1R, and proposes IGFRIL as a novel actionable target for HCC patients.
Jing Zhang   +28 more
wiley   +1 more source

Microphysiological Solid Tumor Models in Hydrogel Beads for CAR T Cell Immunotherapy Evaluation

open access: yesAdvanced Science, EarlyView.
The complex physical and biochemical barriers of the tumor microenvironment are major triggers of immune exclusion. Here, a 3D micrometastasis model is developed to mimic key microenvironmental cues, enabling in vitro evaluation of chimeric antigen receptor (CAR) T cell immunotherapy. Abstract Micrometastases are challenging to resect surgically and to
Xuan Peng   +14 more
wiley   +1 more source

Emirates Society of Radiation Oncology (ESRO): Advancing Cancer Care in the UAE. [PDF]

open access: yesCureus
Shanbhag NM   +5 more
europepmc   +1 more source

Three discipline collaborative radiation therapy (3DCRT) special debate: Equipment development is stifling innovation in radiation oncology [PDF]

open access: yes, 2011
Kim, Leonard   +8 more
core   +1 more source

Intensity modulated radiation therapy for squamous cell carcinoma of the vulva: Treatment technique and outcomes [PDF]

open access: yes, 2017
Chundury, Anupama   +8 more
core   +2 more sources

SNORA58 Facilitates Radioresistance via Suppressing JNK1‐Mediated Ferroptosis in Esophageal Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
In ESCC patients, SNORA58 exhibits heterogeneous expression patterns. Its aberrant overexpression stabilizes CTCF by inhibiting ubiquitin‐mediated degradation, leading to the attenuation of JNK1‐mediated ferroptosis induced by radiotherapy through disruption of intracellular iron homeostasis, and ultimately contributes to radioresistance ...
Yinli Zheng   +14 more
wiley   +1 more source

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