Results 21 to 30 of about 70,075 (241)

RadOnc-GPT: A Large Language Model for Radiation Oncology [PDF]

open access: yesarXiv, 2023
This paper presents RadOnc-GPT, a large language model specialized for radiation oncology through advanced tuning methods. RadOnc-GPT was finetuned on a large dataset of radiation oncology patient records from the Mayo Clinic in Arizona. The model employs instruction tuning on three key tasks - generating radiotherapy treatment regimens, determining ...
arxiv  

Harnessing Automation in Data Mining: A Review on the Impact of PyESAPI in Radiation Oncology Data Extraction and Management [PDF]

open access: yesarXiv, 2023
Data extraction and management are crucial components of research and clinical workflows in Radiation Oncology (RO), where accurate and comprehensive data are imperative to inform treatment planning and delivery. The advent of automated data mining scripts, particularly using the Python Environment for Scripting APIs (PyESAPI), has been a promising ...
arxiv  

Nanotechnology in Radiation Oncology

open access: yesHematology/Oncology Clinics of North America, 2019
Nanotechnology has made remarkable contributions to clinical oncology. Nanotherapeutics and diagnostic tools have distinctive characteristics which allow them superior abilities to deliver therapeutics and imaging agents for radiation oncology. Compared to solid biopsies and imaging, the analysis of circulating tumor cells (CTCs) offers a more rapid ...
Andrew Z. Wang   +3 more
openaire   +3 more sources

NCI Workshop on Artificial Intelligence in Radiation Oncology: Training the Next Generation [PDF]

open access: yes, 2019
Artificial intelligence (AI) is about to touch every aspect of radiotherapy from consultation, treatment planning, quality assurance, therapy delivery, to outcomes modeling. There is an urgent need to train radiation oncologists and medical physicists in data science to help shepherd AI solutions into clinical practice.
arxiv   +1 more source

An Introduction to Natural Language Processing Techniques and Framework for Clinical Implementation in Radiation Oncology [PDF]

open access: yesarXiv, 2023
Natural Language Processing (NLP) is a key technique for developing Medical Artificial Intelligence (AI) systems that leverage Electronic Health Record (EHR) data to build diagnostic and prognostic models. NLP enables the conversion of unstructured clinical text into structured data that can be fed into AI algorithms.
arxiv  

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

open access: yesMolecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam   +2 more
wiley   +1 more source

Exploring the Capabilities and Limitations of Large Language Models for Radiation Oncology Decision Support [PDF]

open access: yesInternational Journal of Radiation Oncology, Biology, Physics. 2024 Mar 15;118(4):900-4
Thanks to the rapidly evolving integration of LLMs into decision-support tools, a significant transformation is happening across large-scale systems. Like other medical fields, the use of LLMs such as GPT-4 is gaining increasing interest in radiation oncology as well.
arxiv   +1 more source

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

open access: yesMolecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park   +6 more
wiley   +1 more source

Deep Learning-based Protoacoustic Signal Denoising for Proton Range Verification [PDF]

open access: yesarXiv, 2022
Objective: Proton therapy offers an advantageous dose distribution compared to the photon therapy, since it deposits most of the energy at the end of range, namely the Bragg peak (BP). Protoacoustic technique was developed to in vivo determine the BP locations. However, it requires large dose delivery to the tissue to obtain an averaged acoustic signal
arxiv  

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

open access: yesMolecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen   +6 more
wiley   +1 more source

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