Results 71 to 80 of about 931,154 (287)

Insight on the properties of thermoplastic elastomer-based natural rubber and recycled rubber post-treated with electron beam irradiation

Materials Research Express, 2021
Thermoplastic elastomers are an indispensable group of materials used in various relevant industries. This study aims to enhance the properties of thermoplastic elastomers by blending the same ratio of natural rubber (NR) and recycled rubber (RR) with ...
Siti Fatahiyah Mohamad, Hasnul Nizam Bin Osman, Muhamad Nurfalah Bin Karoji, Pairu Ibrahim, Syeed SaifulAzry Osman Al Edrus, Lee Seng Hua, Nik Muhammad Faris Hakimi Abd Rahim, Chuah Teong Guan   +7 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Dominant Scattering Mechanism Identification From Quad-Pol-SAR Data Analysis

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Polarimetric decompositions are used to separate scatterers and identify their physical parameters by analyzing backscattering, coherence, or covariance matrices.
Dehbia Hanis, Karima Hadj-Rabah, Aichouche Belhadj-Aissa, Luca Pallotta   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Convolutional Neural Network (CNN) Based Three Dimensional Tumor Localization Using Single X-Ray Projection

IEEE Access, 2019
Accurate localization of lung tumor in real time based on a single X-ray projection is of great interest to the tumor-tracking radiotherapy but is very challenging.
Ran Wei, Fugen Zhou, Bo Liu, Xiangzhi Bai, Dongshan Fu, Yongbao Li, Bin Liang, Qiuwen Wu   +7 more
doaj   +1 more source

Recent results on GaAs detectors - 137 [PDF]

, 1997
The present understanding of the charge collection in GaAs detectors with respect to the materials used and its processing are discussed. The radiation induced degradation of the charge collection efficiency and the leakage current of the detectors are ...
Adams, Alietti, Bates, Beaumont, Berwick, Berwick, C Da Vià, C Raine, Chmill, Da Via, Gorfine, K.M Smith, M Campbell, Manolopoulos, Nava, Nava, R.L Bates, S D'Auria, Schmid, Sloan, Spencer, Toporowsky, V O'Shea, Xiao   +23 more
core   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source