Results 41 to 50 of about 663,209 (281)

Cellular transport of uranium and its cytotoxicity effects on CHO-k1 cells

Ecotoxicology and Environmental Safety, 2022
Uranium is a radioactive heavy metal and a significant public health concern; however, its associated underlying toxicological mechanisms remain largely unknown.
Liqun Huang, Shufang Li, Wenhua Zhou, Jie Gao, Jingjing Yin, Zhongwen Wang, Jianguo Li   +6 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

What evidence exists on the impact of anthropogenic radiofrequency electromagnetic fields on animals and plants in the environment: a systematic map

Environmental Evidence, 2023
Background Exposure to radiofrequency (RF) electromagnetic fields (EMF), particularly from telecommunications sources, is one of the most common and fastest growing anthropogenic factors on the environment.
Ken Karipidis, Chris Brzozek, Rohan Mate, Chhavi Raj Bhatt, Sarah Loughran, Andrew W Wood   +5 more
doaj   +1 more source

The micronucleus assay as a biological dosimeter of in vivo ionising radiation exposure [PDF]

, 2010
Biological dosimetry, based on the analysis of micronuclei (MN) in the cytokinesis-block micronucleus (CBMN) assay can be used as an alternative method for scoring dicentric chromosomes in the field of radiation protection.
Fenech, Michel, Thierens, Hubert, Vral, Anne   +2 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Hydrophobic modification and filtration performance of glass fiber filter material

Cailiao gongcheng
The closed-cycle process will generate a large number of radioactive aerosols, and its high humidity, high acidity, and high radioactivity lead to rapid failure and high replacement frequency of glass fiber high-efficiency filters.
CHEN Xin, YU Jie, LI Yongguo, LI Xin, LIN Zhongxin, PEI Jianlu, ZHENG Qin, LIU Tao, ZHANG Zhaochen, LIU Jingguo, ZHANG Jirong   +10 more
doaj   +1 more source

Shielding analysis in the design phase of the new Emergency Operation Facility for Tihange Nuclear Power Plant

EPJ Web of Conferences, 2017
In the framework of the design studies for a new Emergency Operation Facility (EOF) for Tihange NPP, radiation protection analyses are needed to comply with effective dose rate criteria.
Genard Gilles, Portal Romain, Bouchat Virginie, Vanderperre Serge   +3 more
doaj   +1 more source

A bibliographical review on the concept of biological effects of ionizing radiation in Brazilian publications

Brazilian Journal of Radiation Sciences, 2021
At the end of the nineteenth century, with the use of ionizing radiation for the benefit of humanity in various sectors of society, its effects on human health became evident.
Gabriel De Lima Gonçalves, José Ubiratan Delgado, Fernando Barcellos Razuck   +2 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source