Results 41 to 50 of about 199,878 (267)

Toxic effects of combined exposure of tritiated water and genistein on the growth and development of zebrafish and its mechanism

Frontiers in Environmental Science, 2022
Water pollution and control are important issues of our lasting concern. Environmental media often contains a variety of compounds. Tritium is widely present in nature due to human activities. As an endocrine disruptor, genistein is widely found in water
Fengmei Cui, Fengmei Cui, Qixuan Zhang, Qixuan Zhang, Jun Wan, Jun Wan, Liang Sun, Liang Sun, Na Chen, Na Chen, Huiyuan Xue, Huiyuan Xue, Tianzi Wang, Tianzi Wang, Fajian Luo, Fajian Luo, Qiu Chen, Qiu Chen, Yu Tu, Yu Tu   +19 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Efficient adsorption of Sr2+ from simulated high-level liquid waste by 4A zeolite

BMC Chemistry
The effective separation of radioactive strontium-90 (90Sr) from high-level liquid waste (HLLW) produced by the PUREX process is essential for enhancing nuclear waste disposal safety and minimizing related expenses.
Xiang Qin, Xiliang Guo, Xia Tao, Chao Gao, Xiaojun Yan, Wenfu Yan   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Hydrophobic modification and filtration performance of glass fiber filter material

Cailiao gongcheng
The closed-cycle process will generate a large number of radioactive aerosols, and its high humidity, high acidity, and high radioactivity lead to rapid failure and high replacement frequency of glass fiber high-efficiency filters.
CHEN Xin, YU Jie, LI Yongguo, LI Xin, LIN Zhongxin, PEI Jianlu, ZHENG Qin, LIU Tao, ZHANG Zhaochen, LIU Jingguo, ZHANG Jirong   +10 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

A comparative study on the dose–effect of low-dose radiation based on microdosimetric analysis and single-cell sequencing technology

Scientific Reports
The biological mechanisms triggered by low-dose exposure still need to be explored in depth. In this study, the potential mechanisms of low-dose radiation when irradiating the BEAS-2B cell lines with a Cs-137 gamma-ray source were investigated through ...
Yidi Wang, Jin Gao, Bo Tang, Wei Mo, Han Gao, Jiahao Guo, Xianghui Kong, Wenyue Zhang, Yuchen Yin, Yang Jiao, Liang Sun   +10 more
doaj   +1 more source

Cellular transport of uranium and its cytotoxicity effects on CHO-k1 cells

Ecotoxicology and Environmental Safety, 2022
Uranium is a radioactive heavy metal and a significant public health concern; however, its associated underlying toxicological mechanisms remain largely unknown.
Liqun Huang, Shufang Li, Wenhua Zhou, Jie Gao, Jingjing Yin, Zhongwen Wang, Jianguo Li   +6 more
doaj   +1 more source