Results 81 to 90 of about 4,243,534 (405)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

A comparative study on the dose–effect of low-dose radiation based on microdosimetric analysis and single-cell sequencing technology

Scientific Reports
The biological mechanisms triggered by low-dose exposure still need to be explored in depth. In this study, the potential mechanisms of low-dose radiation when irradiating the BEAS-2B cell lines with a Cs-137 gamma-ray source were investigated through ...
Yidi Wang, Jin Gao, Bo Tang, Wei Mo, Han Gao, Jiahao Guo, Xianghui Kong, Wenyue Zhang, Yuchen Yin, Yang Jiao, Liang Sun   +10 more
doaj   +1 more source

Omics in Radiation Biology: Surprised but Not Disappointed

Radiation, 2022
High-throughput omics platforms have pioneered our approach to understanding biological and cellular processes. Omics technologies provide powerful tools for studying various molecules, such as genes, proteins, and metabolites, in a particular state and ...
Prabal Subedi, Simone Moertl, Omid Azimzadeh   +2 more
doaj   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Research progress on three different types of noncoding RNAs related to ionizing radiation

Radiation Medicine and Protection, 2021
Non-coding RNAs (ncRNAs) have attracted wide attention in the field of ionizing radiation (IR). They have been found to be involved in cell development, proliferation, differentiation, and apoptosis in both clinical radiotherapy and radiation protection ...
Jin Gao, Xumin Zong, Na Chen, Tingxi Lan, Wentao Yu, Huiqiang Long, Fengmei Cui, Yu Tu   +7 more
doaj   +1 more source

Personalised electronic messages to improve sun protection in young adults [PDF]

, 2012
The incidence of all skin cancers, including melanoma, continues to rise. It is well known that ultraviolet (UV) radiation is the main environmental risk factor for skin cancer, and excessive exposure at a young age increases the risk of developing skin ...
Alison Marshall, Cameron Hurst, Glanz K, H Peter Soyer, Hosmer DW, Jans NK, Monika Janda, Philippa Youl, Sarah Mair, Sheeran P   +9 more
core   +2 more sources

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

FEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh, Esther Lee, Soo‐A Kim   +2 more
wiley   +1 more source

Anti-Oxidative and Immuno-Protective Effect of Camel Milk on Radiation-Induced Intestinal Injury in C57BL/6 J Mice

Dose-Response, 2021
Purpose: The main objective is to investigate the protective effect of camel milk (CM) on radiation-induced intestinal injury. Methods: The C57BL/6 J mice in 2 experiments were assigned into control group (Con), irradiation group (IR), and CM+irradiation
Yu-Zhong Chen, Chao Li, Jia Gu, Si-chen Lv, Jia-ying Song, Zhi-bing Tang, Guang-Xin Duan, Li-Qiang Qin, Lin Zhao, Jia-Ying Xu   +9 more
doaj   +1 more source