Results 101 to 110 of about 6,788,828 (423)

Radiation therapy after radical prostatectomy for prostate cancer: evaluation of complications and influence of radiation timing on outcomes in a large, population-based cohort. [PDF]

, 2015
PURPOSE: To evaluate the influence of timing of salvage and adjuvant radiation therapy on outcomes after prostatectomy for prostate cancer. METHODS: Using the Surveillance, Epidemiology, and End Results-Medicare linked database, we identified prostate ...
Dicker, Adam, MD, PhD, Hegarty, Sarah E, Hyslop, Terry, Showalter, Timothy, MD   +3 more
core   +2 more sources

Neutron Therapy in the 21st Century [PDF]

arXiv, 2014
The question of whether or not neutron therapy works has been answered. It is a qualified yes, as is the case with all of radiation therapy. But, neutron therapy has not kept pace with the rest of radiation therapy in terms of beam delivery techniques.
arxiv  

Bystander effects and their implications for clinical radiation therapy: Insights from multiscale in silico experiments [PDF]

, 2014
Radiotherapy is a commonly used treatment for cancer and is usually given in varying doses. At low radiation doses relatively few cells die as a direct response to radiation but secondary radiation effects such as DNA mutation or bystander effects affect many cells.
arxiv   +1 more source

Fractionation in radiation therapy

International Journal of Radiation Oncology*Biology*Physics, 1987
Variations in schedule from the usual 200 cGy daily, 5 days a week, for six or seven weeks, will be reviewed with both the radiobiological basis and clinical results so far. Hyperfractionated schedules (e.g., 1.15 Gy b.i.d. for 7 weeks) have given lo-15% better local control than the conventional 7-week schedule, with no extra late effects, both in ...
openaire   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Stereotactic body radiation therapy for inoperable early stage lung cancer.

Journal of the American Medical Association (JAMA), 2010
CONTEXT Patients with early stage but medically inoperable lung cancer have a poor rate of primary tumor control (30%-40%) and a high rate of mortality (3-year survival, 20%-35%) with current management.
R. Timmerman, R. Paulus, J. Galvin, J. Michalski, W. Straube, J. Bradley, A. Fakiris, A. Bezjak, G. Videtic, D. Johnstone, J. Fowler, E. Gore, H. Choy   +12 more
semanticscholar   +1 more source

miR-142-3p attenuates breast cancer stem cell characteristics and decreases radioresistance in vitro

Tumor Biology, 2018
Effectively targeting cancer stem cells, a subpopulation of tumorigenic, aggressive, and radioresistant cells, holds therapeutic promise. However, the effects of the microRNA miR-142-3p, a small endogenous regulator of gene expression on breast cancer ...
Fabian M Troschel, Nicolas Böhly, Katrin Borrmann, Timo Braun, Alexander Schwickert, Ludwig Kiesel, Hans Theodor Eich, Martin Götte, Burkhard Greve   +8 more
doaj   +1 more source

Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced esophageal squamous cell carcinoma

Radiation Oncology, 2018
Background The purpose of this study was to perform a dosimetric comparison between proton beam therapy (PBT) and photon radiation therapy in patients with locally advanced esophageal squamous cell carcinoma (ESCC) who were treated with PBT in our ...
Yasuhiro Hirano, Masakatsu Onozawa, Hidehiro Hojo, Atsushi Motegi, Sadatomo Zenda, Kenji Hotta, Shunsuke Moriya, Hidenobu Tachibana, Naoki Nakamura, Takashi Kojima, Tetsuo Akimoto   +10 more
doaj   +1 more source

Hospital Quality Factors Influencing the Mobility of Patients for Radical Prostate Cancer Radiation Therapy: A National Population-Based Study. [PDF]

, 2017
PURPOSE: To investigate whether patients requiring radiation treatment are prepared to travel to alternative more distant centers in response to hospital choice policies, and the factors that influence this mobility. METHODS AND MATERIALS: We present the
Aggarwal, Ajay, Charman, Susan C, Lewis, Daniel, Mason, Malcolm, Payne, Heather, Sujenthiran, Arunan, Sullivan, Richard, van der Meulen, Jan   +7 more
core   +4 more sources

Germline variants in CDKN2A wild‐type melanoma prone families

Molecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen, Marie Loeng, Amalie Lund Holth, Per E. Lønning, Jürgen Geisler, Stian Knappskog   +5 more
wiley   +1 more source