Results 51 to 60 of about 758,858 (279)

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

EFFECT OF INTENSE MAGNETIC FIELDS ON THE TRAJECTORY OF ELECTRONSPROPAGATING IN LOW DENSITY MEDIA OF INTEREST FOR MRI-LINAC RADIOTHERAPY

Anales (Asociación Física Argentina), 2023
Ionizing radiation transport mechanisms in presence of magnetic fields can be described in terms of formalisms based on the Boltzmann radiation transport equation. However, when the transport occurs not in vacuum but in scattering media the difficulty of
A. Gayol, M. Valente
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Coupling Radiation Transport and Track-Structure Simulations: Strategy Based on Analytical Formulas Representing DNA Damage Yields

Frontiers in Physics, 2021
Existing radiation codes for biomedical applications face the challenge of dealing with largely different spatial scales, from nanometer scales governing individual energy deposits to macroscopic scales of dose distributions in organs and tissues in ...
Pavel Kundrát, Pavel Kundrát, Werner Friedland, Andrea Ottolenghi, Giorgio Baiocco   +4 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

DNA damage induction during localized chronic exposure to an insoluble radioactive microparticle

Scientific Reports, 2019
Insoluble radioactive microparticles emitted by the incident at the Fukushima nuclear power plant have drawn keen interests from the viewpoint of radiation protection.
Yusuke Matsuya, Yukihiko Satou, Nobuyuki Hamada, Hiroyuki Date, Masayori Ishikawa, Tatsuhiko Sato   +5 more
doaj   +1 more source

4-Methylumbelliferone administration enhances radiosensitivity of human fibrosarcoma by intercellular communication

Scientific Reports, 2021
Hyaluronan synthesis inhibitor 4-methylumbelliferone (4-MU) is a candidate of radiosensitizers which enables both anti-tumour and anti-metastasis effects in X-ray therapy.
Ryo Saga, Yusuke Matsuya, Rei Takahashi, Kazuki Hasegawa, Hiroyuki Date, Yoichiro Hosokawa   +5 more
doaj   +1 more source

Directing transport by polarized radiation in presence of chaos and dissipation

, 2004
We study numerically the dynamics of particles on the Galton board of semi-disk scatters in presence of monochromatic radiation and dissipation. It is shown that under certain conditions the radiation leads to appearance of directed transport linked to ...
A. A. Bykov, A. A. Bykov, A. A. Bykov, A. A. Bykov, A. D. Chepelianskii, D. L. Shepelyansky, E. Ott, F. Galton, I. P. Kornfeld   +8 more
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK

Molecular Cancer, 2008
Background To elucidate the role of src kinase in caveolin-1 driven internalization and nuclear transport of EGFR linked to regulation of DNA-repair in irradiated cells.
Rodemann H Peter, Kehlbach Rainer, Mayer Claus, Dittmann Klaus   +3 more
doaj   +1 more source