Results 91 to 100 of about 2,417,103 (345)

Widespread adaptive evolution during repeated evolutionary radiations in New World lupins

Nature Communications, 2016
The evolutionary processes that drive rapid species diversification are poorly understood. In particular, it is unclear whether Darwinian adaptation or non-adaptive processes are the primary drivers of explosive species diversifications.
B. Nevado, Guy W. Atchison, C. Hughes, D. Filatov   +3 more
semanticscholar   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

ARAMIS: a Martian radiative environment model built from GEANT4 simulations

Journal of Space Weather and Space Climate
A new model of the Martian surface radiative environment has been built: Atmospheric RAdiation Model for Ionizing spectra on martian Surface (ARAMIS). Based on Monte Carlo calculations, it offers high computational flexibility for surface flux spectra ...
Charpentier Gabin, Ruffenach Marine, Benacquista Rémi, Ecoffet Robert, Cappe Alexandre, Dossat Cédric, Varotsou Athina, Cintas Hugo, Paillet Alexis, Boyer Laure, Mekki Julien, Valet Philippe, Gourinat Yves   +12 more
doaj   +1 more source

As old as the mountains: the radiations of the Ericaceae.

New Phytologist, 2015
Mountains are often more species-rich than lowlands. This could be the result of migration from lowlands to mountains, of a greater survival rate in mountains, or of a higher diversification rate in mountains.
Orlando Schwery, R. Onstein, Y. Bouchenak‐Khelladi, Yaowu Xing, R. Carter, H. Linder   +5 more
semanticscholar   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

The netrin-1 receptor UNC5C contributes to the homeostasis of undifferentiated spermatogonia in adult mice

Stem Cell Research, 2022
In adult testis, the cell mobility is essential for spermatogonia differentiation and is suspected to regulate spermatogonial stem cell fate. Netrin-1 controls cell migration and/or survival according to the cellular context. Its involvement in some self-
Vilma Barroca, Chrystele Racine, Laurent Pays, Pierre Fouchet, Mathieu Coureuil, Isabelle Allemand   +5 more
doaj  

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Impact of the hypoxic microenvironment on spermatogonial stem cells in culture

Frontiers in Cell and Developmental Biology
The stem cell niche plays a crucial role in the decision to either self-renew or differentiate. Recent observations lead to the hypothesis that O2 supply by blood and local O2 tension could be key components of the testicular niche of spermatogonial stem
A. S. Gille, A. S. Gille, A. S. Gille, A. S. Gille, M. Givelet, M. Givelet, M. Givelet, M. Givelet, D. Pehlic, D. Pehlic, C. Lapoujade, C. Lapoujade, B. Lassalle, B. Lassalle, V. Barroca, V. Barroca, A. P. Bemelmans, D. Borderie, D. Borderie, D. Moison, D. Moison, G. Livera, G. Livera, L. R. Gauthier, L. R. Gauthier, F. D. Boussin, F. D. Boussin, N. Thiounn, I. Allemand, I. Allemand, C. Peyssonnaux, C. Peyssonnaux, J. P. Wolf, J. P. Wolf, V. Barraud-Lange, V. Barraud-Lange, L. Riou, L. Riou, P. Fouchet, P. Fouchet   +39 more
doaj   +1 more source

Process and pattern in cichlid radiations - inferences for understanding unusually high rates of evolutionary diversification.

New Phytologist, 2015
The cichlid fish radiations in the African Great Lakes differ from all other known cases of rapid speciation in vertebrates by their spectacular trophic diversity and richness of sympatric species, comparable to the most rapid angiosperm radiations.
O. Seehausen
semanticscholar   +1 more source