Results 31 to 40 of about 205,946 (247)

Radiative forcing and feedback by forests in warm climates – a sensitivity study [PDF]

Earth System Dynamics, 2016
We evaluate the radiative forcing of forests and the feedbacks triggered by forests in a warm, basically ice-free climate and in a cool climate with permanent high-latitude ice cover using the Max Planck Institute for Meteorology Earth System Model. As a
U. Port, M. Claussen, V. Brovkin
doaj   +1 more source

Assessing 20th century climate-vegetation feedbacks of land-use change and natural vegetation dynamics in a fully coupled vegetation-climate model [PDF]

, 2010
This study describes the coupling of the dynamic global vegetation model (DGVM), Lund–Potsdam–Jena Model for managed land (LPJmL), with the general circulation model (GCM), Simplified Parameterizations primitivE Equation DYnamics model (SPEEDY), to study
Bart J. Strengers, Roy van den Houdt, Severijns, C., Camiel Severijns, Strengers, B., Schaeffer, M., Oostenrijk, R., Houdt, R., Van den, Dieter Gerten, Haarsma, R.J., Strengers, B.J., Müller, C., Christoph Müller, Gerten, D., Schaphoff, S., Michiel Schaeffer, Reindert J. Haarsma, Rineke Oostenrijk, Van den Houdt, R., Sibyll Schaphoff, Haarsma, R.   +20 more
core   +1 more source

Technical note: Recommendations for diagnosing cloud feedbacks and rapid cloud adjustments using cloud radiative kernels [PDF]

Atmospheric Chemistry and Physics
The cloud radiative kernel method is a popular approach to quantify cloud feedbacks and rapid cloud adjustments to increased CO2 concentrations and to partition contributions from changes in cloud amount, altitude, and optical depth.
M. D. Zelinka, L.-W. Chao, T. A. Myers, T. A. Myers, Y. Qin, S. A. Klein   +5 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Distortions of the Rain Distribution With Warming, With and Without Self‐Aggregation

Journal of Advances in Modeling Earth Systems, 2021
We investigate how mesoscale circulations associated with convective aggregation can modulate the sensitivity of the hydrologic cycle to warming. We quantify changes in the full distribution of rain across radiative‐convective equilibrium states in a ...
Benjamin Fildier, William D. Collins, Caroline Muller   +2 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Atmospheric radiative feedbacks associated with transient climate change and climate variability

, 2010
This study examines in detail the 'atmospheric' radiative feedbacks operating in a coupled General Circulation Model (GCM). These feedbacks (defined as the change in top of atmosphere radiation per degree of global surface temperature change) are due to ...
Colman, Robert A., Power, Scott B.
core   +1 more source

Evaluating the Role of Kernel Choice on Radiative Feedback Estimates

Geophysical Research Letters
Radiative feedbacks are important for understanding climate sensitivity, yet estimates vary widely across climate models. Feedbacks are often computed using the radiative kernel technique, which uses pre‐calculated radiative sensitivities (kernels ...
Kaitlyn Wen, Ivan Mitevski, Tyler P. Janoski, Gabriel A. Vecchi   +3 more
doaj   +1 more source

How Well do We Understand the Planck Feedback?

Journal of Advances in Modeling Earth Systems, 2023
A reference or “no‐feedback” radiative response to warming is fundamental to understanding how much global warming will occur for a given change in greenhouse gases or solar radiation incident on the Earth.
Timothy W. Cronin, Ishir Dutta
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source