Results 61 to 70 of about 20,799 (303)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Aerosol modeling over Europe: 2. Interannual variability of aerosol shortwave direct radiative forcing

, 2007
Aerosol distribution over Europe and its direct radiative forcing have been simulated with a regional atmosphere-chemistry model and an off-line radiation transfer model. Primary and secondary organic and inorganic aerosols have been considered.
Hungershöfer, K., Marmer, Elina, Langmann, B., Hungershöfer, Katja, Langmann, Bärbel, Trautmann, Thomas, Trautmann, T., Marmer, E.   +7 more
core   +1 more source

Relative contributions to surface shortwave irradiance over China: A new index of potential radiative forcing [PDF]

, 2008
The contributions of atmospheric factors to surface shortwave irradiance (S) variability was investigated, using radiative transfer calculations to examine all sky (both cloud-free and cloudy) conditions. We defined the sensitivities of S to differential
Hayasaka, Tadahiro, Kawamoto, Kazuaki
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Aerosol Direct Radiative Effects over China Based on Long-Term Observations within the Sun–Sky Radiometer Observation Network (SONET)

Remote Sensing, 2020
To investigate aerosol radiative effects, the Sun–Sky Radiometer Observation Network (SONET) has performed long-term observations of columnar atmospheric aerosol properties at 20 distributed stations around China. The aerosol direct radiative forcing (RF)
Li Li, Zhengqiang Li, Kaitao Li, Yan Wang, Qingjiu Tian, Xiaoli Su, Leiku Yang, Song Ye, Hua Xu   +8 more
doaj   +1 more source

Technical Note: Estimating aerosol effects on cloud radiative forcing [PDF]

Atmospheric Chemistry and Physics, 2013
Estimating anthropogenic aerosol effects on the planetary energy balance through the aerosol influence on clouds using the difference in cloud radiative forcing from simulations with and without anthropogenic emissions produces estimates that are ...
S. J. Ghan
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Separating the shortwave and longwave components of greenhouse gas radiative forcing

Atmospheric Science Letters, 2022
Many important greenhouse gases (including water vapour, carbon dioxide, methane and ozone) absorb solar radiation. When gas concentrations change, this absorption exerts a radiative forcing that modifies the thermal infrared (‘longwave’) radiative ...
Keith P. Shine, Rachael E. Byrom, Ramiro Checa‐Garcia   +2 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Quantifying Impacts of CO2 Radiative and Vegetation Physiological Forcing on Land Potential Evapotranspiration and Dryness/Wetness Changes Under a High CO2 Emissions Scenario

Water Resources Research
Increased atmospheric CO2 affects climate through radiative and physiological forcing, but their specific roles in the transient changes in future potential evapotranspiration (PET) and dryness/wetness remain unclear.
Shanlei Sun, Jialing Xu, Qianrong Ma, Yifang Zhang, Qianxue Zu, Mengyuan Mu, Wenjian Hua, Yang Zhou, Botao Zhou   +8 more
doaj   +1 more source