Results 131 to 140 of about 83,373 (311)
The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation
Advanced Science, EarlyView.ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley +1 more source
Review of \u3cem\u3eThe Loyal West: Civil War and Reunion in Middle America\u3c/em\u3e by Matthew E. Stanley [PDF]
, 2018 Interest in Civil War memory and post–Civil War sectional reconciliation has expanded greatly in recent years, as two 2016 historiographical essays attest.1 Matthew E. Stanley\u27s new book, The Loyal West: Civil War and Reunion in Middle America is thus
Harris, M. Keith +4 more
core +1 more source
Advanced Science, EarlyView.We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim +6 more
wiley +1 more source
Defeaters in current epistemology: introduction to the special issue [PDF]
, 2017 Moretti, Luca, Piazza, Tommaso
core +1 more source
Advanced Science, EarlyView.Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang +18 more
wiley +1 more source
Liberal Islam versus Moderate Islam
American Journal of Islam and Society, 2005 There is a tendency to equate liberal Islam with moderate Islam. Yet there are occasions when to be liberal demands a sense of outrage and rebellion.
Ali A. Mazrui
doaj
Advanced Science, EarlyView.This study employs longitudinal fluorescence imaging in transgenic mice to map post‐craniotomy cortical recovery. We identify distinct neuroimmune recovery phases: microglial structural inflammation peaks at ∼10 days, neuronal structural intensity peaks at ∼14 days and correlates with microglial activity, and functional network modularity is most ...
Guihua Xiao +13 more
wiley +1 more source
Southern African Journal of Environmental Education, 2005 The paper reviews education activities in a successful anti-cholera campaign amongst rural communities in eastern southern Africa. It is centred on probing how a modern institutional governmentality was relatively blind to an historical legacy of Nguni ...
Rob O'Donoghue
doaj
Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors
Advanced Science, EarlyView.This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su +15 more
wiley +1 more source
'A Balance of Power that Favors Freedom'. The Historical and Ideological Roots of the Neo-Conservative Persuasion [PDF]
The paper offers a genealogy of neoconservatism, concentrating on its ideological and historical foundations in the early 1970s. In the first part, it shows how neoconservatism represented a reaction to the crisis-real and perceived-the United States was
Mario del Pero
core