Results 51 to 60 of about 83,373 (311)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

WhatsApp and political instability in Brazil: targeted messages and political radicalisation

Internet Policy Review, 2019
In the 2018 presidential election, Brazil elected a fringe congressman, Jair Bolsonaro, despite his radical rhetoric that would suffice to shake the public image of any candidate in the world and the lack of traditional resources of his campaign.
Rafael Evangelista, Fernanda Bruno
doaj   +1 more source

Competing ideologies of Russia's civil society [PDF]

, 2015
Many analysts and public opinion makers in the West conflate the notions of Russia’s non-systemic liberal opposition and the country’s civil society.
Byzov L., Chebankova E., Delyagin M., Delyagin M., Dugin A., Dzhemal G., Elena Chebankova, FOM, ISPI RAN, Krasin Yu., Leontev M., Levada Centre, Levada Centre, Levada Centre, Mamanov M., Martynov K., Narochnitskaya N., Nosikov R., Prokhanov A., Putin V., Shevchenko M., Shevchenko M., Shevchenko M., Shevchenko M., Shevchenko M., Soboleva I., Tretyakov V., Tretyakov V., Tretyakov V., Tretyakov V., Tretyakov V., Tretyakov V., Tretyakov V., Tretyakov V., VTsIOM, VTsIOM, Zevina O.   +36 more
core   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Edmund Burke and the German conservative political thought in the first half of the XX-th century

RUDN Journal of Political Science, 2009
The developments of conservatism in many respects are conditioned by political changes, descending in society. The main problem of conservatism is to correct these changes to not enable distribution of radical ideas and implementation of them in the ...
N F Zhirnov
doaj  

To Conserve is To Create: a Review of Spinoza’s Paradoxical Conservatism

Journal of Spinoza Studies
In this book, François Zourabichvili addresses three major themes of Spinoza’s philosophy, namely ethical emendation, childhood, and politics. Through the notion of transformation, the author argues that Spinozism is a “paradoxical conservatism” insofar ...
Fabio Carnevali
doaj   +1 more source

Questions about Roger Scruton

American Journal of Islam and Society, 2012
Roger Scruton, known for his good-natured conservatism and general attempts to defend traditional Western life, seems blind to the novelty of our globalized world as he conflates Islam with radical Islam and attacks Muslims as though all were Islamists ...
Charles E. Butterworth
doaj   +1 more source

What Does Salafism Promise to Us? -The Political Theology of Purification and Stability in a Chaotic World-

Kader, 2023
Salafism, derived from the root of ‘Salaf’ in the sense of ‘the former’ as a word, means ‘the path of those who follow the footsteps of the former’ and refers to a kind of religious fanaticism or conservatism.
Mehmet Evkuran, Yusuf Sayın
doaj   +1 more source

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source