Results 211 to 220 of about 249,739 (290)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Effects of Host Genetic Polymorphisms on the Efficacy of the Radical Cure Malaria Drug Primaquine. [PDF]

Am J Trop Med Hyg, 2022
Nain M, Mohan M, Sharma A.
europepmc   +1 more source

The Radical Cure of Gonorrhœal Iritis [PDF]

Proceedings of the Royal Society of Medicine, 1920
openaire   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Addressing health equity for breastfeeding women: primaquine for Plasmodium vivax radical cure. [PDF]

Malar J
Abla N, Marrast AC, Jambert E, Richardson N, Duparc S, Almond L, Rowland Yeo K, Pan X, Tarning J, Zhao P, Culpepper J, Waitt C, Koldeweij C, Cole S, Butler AS, Khier S, Möhrle JJ, El Gaaloul M.   +17 more
europepmc   +1 more source

The empirical support for the radical cure strategy for eliminating Plasmodium vivax in China. [PDF]

BMC Med, 2022
Yang GJ, Shang LY, Zhou XN, Lee TE, Bi B, White M, Smith TA, Penny MA.   +7 more
europepmc   +1 more source

The Radical Cure of Femoral Hernia [PDF]

BMJ, 1900
openaire   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Quantifying Plasmodium vivax radical cure efficacy: a modelling study integrating clinical trial data and transmission dynamics. [PDF]

Lancet Infect Dis
Ciavarella C, Drakeley C, Price RN, Mueller I, White M.   +4 more
europepmc   +1 more source

The radical cure of urethral strictures.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2003
No ...
openaire   +2 more sources