Results 81 to 90 of about 427,861 (368)

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

Visible and Infrared Spectroelectrochemistry of Zinc and Manganese Porphinones: Metal vs. Porphyrin Reduction [PDF]

open access: yes, 2015
The visible and infrared spectroelectrochemistry of zinc and manganese porphinones and porphinediones was carried out in THF solutions. The aim of this work was to use FTIR spectroelectrochemistry and DFT calculation to determine whether the reduction ...
Atifi, Abderrahman   +2 more
core   +1 more source

On elementarity of radical classes of modules over noncommutative dedekind duo-domains

open access: yesKarpatsʹkì Matematičnì Publìkacìï, 2012
We find some sufficient conditions for a radical class of an idempotent radical in the category of modules over a Dedekind left bounded duo-domain to be axiomatizable. In the case of the integer numbers ring this result implies the Gorbachuk-Komarnitskii
Y.T Bilyak, M.Ya Komarnitskii
doaj   +2 more sources

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

On a class of radicals of rings [PDF]

open access: yesJournal of the Australian Mathematical Society. Series A. Pure Mathematics and Statistics, 1995
AbstractLet λ be a property that a lattice of submodules of a module may possess and which is preserved under taking sublattices and isomorphic images of such lattices and is satisfied by the lattice of subgroups of the group of integer numbers. For a ring R the lower radical Λ generated by the class λ(R) of R-modules whose lattice of submodules ...
openaire   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

6-Endo-dig cyclization: Flexible enforce to develop synthetic route in organic syntheses

open access: yesResults in Chemistry, 2023
The organic ring closure reaction of diverse acyclic compounds is governed mostly by the Baldwin rule. The ring closure compounds shows emergent application.
Vembu Yogeshwaran   +3 more
doaj  

Protective Mechanism of the Antioxidant Baicalein toward Hydroxyl Radical-Treated Bone Marrow-Derived Mesenchymal Stem Cells

open access: yesMolecules, 2018
Our study explores the antioxidant and cytoprotective effects of baicalein and further discusses the possible mechanisms. A methyl thiazolyl tetrazolium (MTT) assay revealed that baicalein could considerably enhance the viability of hydroxyl radical ...
Yage Tian   +6 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Properties of Lyubeznik numbers under localization and polarization [PDF]

open access: yes, 2014
We exhibit a global bound for the Lyubeznik numbers of a ring of prime characteristic. In addition, we show that for a monomial ideal, the Lyubeznik numbers of the quotient rings of its radical and its polarization are the same.
Banerjee, Arindam   +2 more
core  

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