Results 111 to 120 of about 1,225,901 (299)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Cultural Threats Versus Economic Insecurities: A Role-Playing Experiment on Supporting Populist Radical Discourses

open access: yesJournal of Social and Political Psychology
Although some scholars have associated cultural threats with radical right support and economic insecurities with radical left support, it has also been highlighted that economic insecurities might drive support for radical right movements.
Lucas Sudbrack, Peter Beattie
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Kurosh-Amitsur Right Jacobson Radical of Type 0 for Right Near-Rings

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2008
By a near-ring we mean a right near-ring. J0r, the right Jacobson radical of type 0, was introduced for near-rings by the first and second authors. In this paper properties of the radical J0r are studied. It is shown that J0r is a Kurosh-Amitsur radical
Ravi Srinivasa Rao   +2 more
doaj   +1 more source

While there are differences, there are also important similarities between the profiles of UKIP and BNP’s respective support bases [PDF]

open access: yes, 2014
While UKIP has seen a rise in support, another party on the right, the BNP, have witnessed a dramatic decline. Heinz Brandenburg and Anders Widfeldt studied the similarities and differences between the UKIP and BNP support bases, finding that BNP fits ...
Brandenburg, Heinz, Widfeldt, Anders
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

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