Results 111 to 120 of about 1,224,999 (294)

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

How polarization, populist attitudes, and cultural backlash affect citizens’ support for democracy: Evidence from Spain

Revista Internacional de Sociología
In recent years, substantial scholarly attention has been devoted to understanding the consequences of three increasing phenomena on democratic legitimacy: populism, polarization, and cultural backlash.
Irene Palacios Brihuega, Antonio Garrido Rubia, Antonia Martínez Rodríguez   +2 more
doaj   +1 more source

Those Awful Tahrir Rapes [PDF]

, 2015
This essay highlights the myriad ways in which street sexual harassment of women in Egypt, of which I argue the mass rapes of Tahrir are an egregious instance thereof, disciplines women\u27s bodies.
Abu-Odeh, Lama
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Politics of Boundary Consolidation: Income Inequality, Ethnonationalism, and Radical-Right Voting

Socius
Scholars have linked income inequality to the recent success of radical-right parties and movements. Yet research shows that inequality reduces participation among groups likely to support the radical right and promotes support for redistribution, an ...
Martin Lukk
doaj   +1 more source

While there are differences, there are also important similarities between the profiles of UKIP and BNP’s respective support bases [PDF]

, 2014
While UKIP has seen a rise in support, another party on the right, the BNP, have witnessed a dramatic decline. Heinz Brandenburg and Anders Widfeldt studied the similarities and differences between the UKIP and BNP support bases, finding that BNP fits ...
Brandenburg, Heinz, Widfeldt, Anders
core  

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

The politics of resentment: what is it and how is it mobilized by populist radical right-wing parties in different contexts?

Frontiers in Political Science
The role of emotions in politics is drawing increasing scholarly attention. Yet, despite this heightened interest, the ways in which politicians concretely appeal to emotions of their target audience are still blurry.
Koen Damhuis, Ekaterina R. Rashkova
doaj   +1 more source

The Reverse Backlash: How the Success of Populist Radical Right Parties Relates to More Positive Immigration Attitudes. [PDF]

Public Opin Q, 2023
Dennison J, Kustov A.
europepmc   +1 more source