Results 31 to 40 of about 885,980 (316)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Mediaciones Sociales, 2008 Pese a la incorporación de la tecnología a la información se revisan determinados comportamientos de literatos que desarrollaron una labor cualitativa en el periodismo, por lo que medialmente se diferencian a los creadores, de los reproductores y de los ...
Vicente González Radío
doaj
Edoardo Sanguineti: «saltimbanco alla radio» between radio dramas and interviews
FinzioniThe essay aims to inquire various radiophonic frequentations and experimentations by Edoardo Sanguineti. In order to do so conspicuous and heterogeneous archivistic material will be inquired, both letters and typescripts, as well as radiophonic ...
Virginia Criscenti
doaj +1 more source
Arbor: Ciencia, Pensamiento y Cultura, 2006 Se estudia la trayectoria artística y profesional de la escritora barcelonesa Lola Salvador Maldonado (Salvador Maldonado), guionista, figurinista y productora cinematográfica y de televisión y radio, así como docente.
José Luis Martínez Montalbán
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
The voice of radio drama in Italy. The case of the magazine «Repertorio»
FinzioniOn 20th April 1949, «Repertorio» began its publications. The magazine, edited by Umberto Colombini, not only published the texts of radio dramas broadcast by Rai, but also featured a wealth of critical essays questioning the artistic and expressive ...
Loredana Palma
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source