Results 31 to 40 of about 2,106 (260)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Experiments with time structure in Tom Stoppard’s dramas [PDF]
Polish Journal of English Studies, 2018 The present study aims to analyse selected plays of Tom Stoppard for the stage and the radio from the perspective of experimenting with time structures.
Jadwiga Uchman
doaj
Acta Universitatis Lodziensis. Folia Litteraria Polonica, 2017 The article deals with the complicated fates of my radio drama Podróż na Księżyc [Journey to the Moon]. In it, I write about the inspiration I drew from the work on an article about the subject of death in early silent cinema.
Monika Milewska
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Radio Drama in Spain: Context of Reference for a Diachronic Approach
Index Comunicación, 2019 The main objective of this article is to give a contextualization of radio drama in Spain, over a period of three decades in the last century, between the 1940s and the 1970s.
María Julia González-Conde +2 more
doaj
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Austriaʼs Legacy in Early Radio Broadcasting: Lessons for Audio Media in the 21st Century [PDF]
Athens Journal of Mass Media and Communications, 2017 Early radio broadcasting represents a vital part of media history. It offers an important foundation of mediated storytelling and other content forms in the first electronic medium of mass communication.
John V. Pavlik
doaj +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source