Results 101 to 110 of about 4,390 (264)

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

Advanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu, Yuyu Wu, Yingjie Chen, Xiyi Chen, Xingjie Zan, Yanlong Liu, Wujun Geng   +6 more
wiley   +1 more source

User privacy prevention model using supervised federated learning‐based block chain approach for internet of Medical Things

CAAI Transactions on Intelligence Technology, EarlyView., 2023
Abstract This research focuses on addressing the privacy issues in healthcare advancement monitoring with the rapid establishment of the decentralised communication system in the Internet of Medical Things (IoMT). An integrated blockchain homomorphic encryption standard with an in‐build supervised learning‐based smart contract is designed to improvise ...
Chandramohan Dhasarathan, Mohammad Kamrul Hasan, Shayla Islam, Salwani Abdullah, Shailesh Khapre, Dalbir Singh, Abdulaziz A. Alsulami, Ali Alqahtani   +7 more
wiley   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

First Results of Airborne GNSS Radio Occultation Sounding From Airbus Commercial Aircraft

Geophysical Research Letters
The lack of high vertical resolution atmospheric thermodynamic structure observations inside or near major weather events impedes our understanding of physical processes and their predictability in numerical weather prediction (NWP) models.
Feiqin Xie, Kevin J. Nelson, Bryan C. Chan, Ashish Goel, Jonathan Kosh, Mike Vergalla   +5 more
doaj   +1 more source

Trans‐A2B2‐Type Metalloporphyrin‐Based Donor–Acceptor Covalent Organic Frameworks for Efficient Photocatalytic CO2 Cycloaddition to Aziridines

Advanced Science, EarlyView.
Two novel trans‐A2B2‐type porphyrin‐based D‐A type covalent organic frameworks (COFs), including metal‐free m‐DBPA‐COF and metallized m‐NiDBPA‐COF, have been successfully synthesized and under visible light‐assisted and mild conditions (1 atm CO2 with no heating required), m‐NiDBPA‐COF exhibits remarkable photocatalytic performance, achieving a ...
Ji Xiong, Minghui Chen, Yunhao Xu, Yaqing Feng, Jian Song, Bao Zhang   +5 more
wiley   +1 more source

First results from the Cassini radio occultations of the Titan ionosphere

, 2008
A. J. Kliore, A. F. Nagy, E. A. Marouf, R. G. French, F. M. Flasar, N. J. Rappaport, Aseel Anabttawi, S. W. Asmar, Daniel S. Kahann, E. Barbinis, G. Goltz, D. Fleischman, D. Rochblatt   +12 more
openalex   +2 more sources

A Trypsin‐Like Serine Protease ZmNAL1a Fine‐Tunes Maize Floral Transition and Flowering Time

Advanced Science, EarlyView.
This study identifies a trypsin‐like serine protease, ZmNAL1a, that moves from leaves to the shoot apical meristem. ZmNAL1a promotes the floral transition by degrading TOPLESS‐like corepressor REL2, which thereby enhances the expression of key flowering genes through elevating histone acetylation and relieving REL2–ZmEREBP147‐mediated transcriptional ...
Nan Li, Qiang Ning, Zhen Li, Qian Zhang, Peilu Zhu, Jimin Zhan, Yunfu Li, Zhen Li, Liang Dong, Qing Xiong, Jiahao Liao, Jie Liu, David Jackson, Munenori Kitagawa, Zuxin Zhang, Lei Liu   +15 more
wiley   +1 more source

Monitoring Urban Heat Island Intensity with Ground-based GNSS Observations and Space-based Radio Occultation and Radiosonde Historical Data

, 2022
Pengfei Xia, Peng Wei, Shirong Ye, Min Guo, Fangxin Hu   +4 more
openalex   +1 more source

Fluorinated Carnitine Derivatives as Tools to Visualise Carnitine Transport and Metabolism

Advanced Science, EarlyView.
Fluorinated carnitines, fluoromethyl carnitine (FMC) and [18F]fluoromethyl carnitine ([18F]FMC), are synthesised and established as powerful probes to interrogate carnitine biology. The multimodal detection facilitated by fluorine labelling, including 19F NMR, mass spectrometry, and positron emission tomography imaging, allowed for visualisation of ...
Richard S. Edwards, Ella‐May Hards, Sofia N. dos Santos, Hannah E. Greenwood, Madeleine E. George, Andrea Emanuelli, Muhammet Tanc, Thomas R. Eykyn, Timothy H. Witney   +8 more
wiley   +1 more source