Results 101 to 110 of about 6,408 (256)

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Technical Assessment of Preclinical Noninvasive Imaging Methods for Endometriosis Follow‐Up in Murine Models

iRADIOLOGY, EarlyView.
This schematic rapidly illustrates the diverse imaging modalities used in preclinical endometriosis research. It highlights optical techniques, such as bioluminescence, fluorescence, and nanoparticle‐assisted imaging, alongside non optical approaches like MRI, ultrasound, and PET, which are key tools in advancing diagnostic precision and understanding ...
Peyman Palay, Tayyebeh Zamani‐Badi, Zeinab Ghezelayagh, Kiandokht Kiani   +3 more
wiley   +1 more source

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto, Daniel Vitor de Souza, Gabriel Carvalhal de Aguiar, Ana Claudia Muniz Renno, Patricia Ramos Cury, Jean Nunes dos Santos, Rogerio Aparecido Dedivitis, Daniel Araki Ribeiro   +7 more
wiley   +1 more source

Bioinorganic Site‐Specific Conjugation of Multi‐Arm Linkers to Create Pharmaceuticals With Targeting and Effector Functions

Journal of the Chinese Chemical Society, EarlyView.
This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel, Tse Wen Chang, Carmay Lim   +2 more
wiley   +1 more source

Discovering Shared Design Heritage for Semiconductor‐Based Gamma‐Ray Spectrometers: From CdTe to Metal Halide Perovskites

Laser &Photonics Reviews, EarlyView.
Decades of CdTe and CdZnTe gamma‐ray spectrometer development define core design principles for room‐temperature semiconductor detectors. This Review highlights how metal halide perovskites rapidly assimilate these principles, particularly through defect and compositional engineering strategies that establish favorable spectroscopic conditions for ...
Younghak Kim, Jiwon Seo, Jihwan Boo, Jaehyeon Seo, Chanho Kim, Geehyun Kim, Jung‐Yeol Yeom, Beomjun Park   +7 more
wiley   +1 more source

Hydrogen Analyses of FSW Cu‐OFP Tested Under Creep Conditions in Sulphide Containing Environment

Materials and Corrosion, EarlyView.
Friction stir welded Cu‐OFP exhibits elevated creep rates in sulphide‐containing aqueous environments, with creep increasing as sulphide concentration rises. Hydrogen measurements indicate that sulphide exposure does not increase hydrogen content. ABSTRACT Friction stir welded oxygen‐free phosphorus‐doped copper (FSW Cu‐OFP) is a candidate material for
Patrik Sahiluoma, Tiina Ikäläinen, Juhani Rantala, Timo Saario   +3 more
wiley   +1 more source

Trace americium contamination sources in the environment can be detected using 243Am/241Am

Communications Earth & Environment
Despite the widespread presence of americium in the environment since the 1950s from nuclear activities, the use of americium isotopic composition to trace contamination sources has not been investigated.
Elena Chamizo, Mercedes López-Lora, Antonio J. López-Fuentes   +2 more
doaj   +1 more source

Gene Therapy for Amino Acid Decarboxylase Deficiency: Clinical and Imaging Outcomes in a French Cohort

Movement Disorders, EarlyView.
Abstract Background Intracerebral gene therapy is effective for amino acid decarboxylase (AADC) deficiency, but relationships between anatomical putaminal coverage, metabolic dynamics, and clinical recovery remain poorly understood. Objectives Assess safety, long‐term efficacy, and clinical–radiological correlations in a genetically diverse European ...
Clément Dunoyer, Gaëtan Poulen, Marie‐Céline François‐Heude, Eline Chauvet‐Piat, Bérénice Lecardonnel, Emmanuel Roze, Marie‐Ange Nguyen Morel, Domitille Gras, Adeline Quintard, Gaelle Baroux, Pierre Meyer, Philippe Coubes, Christophe Milesi, Julien Baleine, Chrystelle Sola, Vivien Szabo, Bénédicte Delye, Jana Haberlova, Mohamed Osman Eltahir Babiker, Mohammed Al Muqbil, Stéphanie Sanchez, Souad Touati, Nicolas Leboucq, Virginie Kouyoumdjian, Sylvia Sanquer, Denis Mariano‐Goulart, Thomas Roujeau, Agathe Roubertie   +27 more
wiley   +1 more source

Repeated Pleistocene Permafrost Episodes in the Western Pannonian Basin

Permafrost and Periglacial Processes, EarlyView.
ABSTRACT Concerning the study of past periglacial processes, the Pannonian Basin is a key area as it contains the southernmost frost polygons found in Central Europe. The presence or absence of permafrost is still, however, a matter of debate, and data on the timing of frost action are also scarce.
Krisztina Sebe, Ágnes Novothny, Gergely Surányi, Barbara Varga, László Fodor, Gábor Csillag   +5 more
wiley   +1 more source

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet, Klas Petersson, Marc C. Huisman, C. Willemien Menke‐van der Houven van Oordt, Iris H. C. Miedema, Andrea Thiele, Ghazal Montaseri, Alejandro Pérez‐Pitarch, David Busse   +8 more
wiley   +1 more source