Results 91 to 100 of about 70,433 (233)
What's new? This study evaluated patient characteristics and treatment strategies in stages II and III HR+/HER2− breast cancer. Neoadjuvant systemic therapy frequently facilitated breast‐conserving procedures and less invasive axillary surgery. Approximately half of the patients undergoing primary surgery received a mastectomy, and all with positive ...
Layla Andour +5 more
wiley +1 more source
ABSTRACT Background Differentiated thyroid carcinoma (DTC) is typically managed surgically with favourable outcomes. However, surgery may have dire consequences when the tumour invades critical structures. Neoadjuvant therapy with tyrosine kinase inhibitors (TKIs) has emerged as a potential strategy to improve resectability and reduce morbidity in ...
Alexandra Dorman +15 more
wiley +1 more source
ABSTRACT Mediated by their protein transduction domain, cell‐penetrating peptides (CPPs) have been widely explored for facilitating intracellular delivery of drugs and small molecules. In this study, a radiolabeled, 2‐nitroimidazole conjugated TAT (TAT ‐ transactivator of transcription) peptide was prepared and evaluated for targeting tumor hypoxia ...
Sweety Mittal +4 more
wiley +1 more source
Impact of repeated dose of stable iodine in an in utero rat model using a metabolomic approach
The Fukushima nuclear power plant blast resulted in the release of 131Iodine for several weeks. This unexpected issue challenged the iodin doctrine [1], in which the counter-measure is to provide a unique iodine tablet to saturate thyroid during the ...
Rosique Clément +3 more
doaj +1 more source
Partial Laryngectomy for Thyroid Cancer: A Single Institution Case Series With Operative Techniques
ABSTRACT Background Partial laryngectomy has been well described as a management option for T1–3 laryngeal squamous cell cancers. However, there are a few case reports of partial laryngeal surgery for locally advanced thyroid carcinoma. Methods This is a case series of five patients with thyroid carcinoma (one primary and four recurrent) with laryngeal
Ella E. Hawes +17 more
wiley +1 more source
Intranasal (IN) delivery of PEGylated PLGA nanoparticles (NPs) loaded with oxytocin (OT) (OT‐NP‐PEG) is investigated as a strategy to enhance OT transport to the brain for treating autism and other neuropsychiatric disorders. The optimized NP formulation demonstrates appropriate physicochemical characteristics, improved stability, and enhanced mucosal ...
Naveed Ahmad +11 more
wiley +1 more source
On-line Excited-State Laser Spectroscopy of Trapped Short-Lived Ra$^+$ Ions [PDF]
As an important step towards an atomic parity violation experiment in one single trapped Ra$^+$ ion, laser spectroscopy experiments were performed with on-line produced short-lived $^{212,213,214}$Ra$^+$ ions. The isotope shift of the $6\,^2$D$_{3/2}$\,-\
Berg, J. E. van den +13 more
core +2 more sources
Togni reagent I, one of the most used electrophilic trifluoromethylating reagents, has been radiolabeled with fluorine‐18 starting from the widely available fluoro‐benziodoxole and the [18F]Ruppert–Prakash reagent. To demonstrate the broad potential for late‐stage functionalization, aliphatic carboxylic acids were successfully converted into their 18F ...
Lizeth Y. F. Haveman +2 more
wiley +1 more source
Papillary Thyroid Cancer (PTC) is the most prevalent type of differentiated thyroid cancer. Its incidence is growing worldwide although it has low death rates. Treatment includes surgery followed by radioactive iodine therapy.
Muntaha Fatima Rana +2 more
doaj +1 more source

