Results 161 to 170 of about 14,306 (313)

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto   +7 more
wiley   +1 more source

Mass balance study of [<sup>14</sup>C]Netanasvir Phosphate in healthy Chinese participants. [PDF]

open access: yesAntimicrob Agents Chemother
Zhao C-y   +12 more
europepmc   +1 more source

Bioinorganic Site‐Specific Conjugation of Multi‐Arm Linkers to Create Pharmaceuticals With Targeting and Effector Functions

open access: yesJournal of the Chinese Chemical Society, EarlyView.
This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel   +2 more
wiley   +1 more source

Radium - from discovery to the present day - narrative review. [PDF]

open access: yesClin Exp Med
Charkiewicz AE   +5 more
europepmc   +1 more source

Improving the Accuracy of Papillary Thyroid Cancer Pathological Evaluation With Digital PCR Detection of the BRAF V600E Mutation

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
This study developed a highly sensitive and specific digital PCR assay for BRAF V600E mutation detection in papillary thyroid cancer (PTC). The increased sensitivity of BRAF mutation detection directly led to more accurate pathological diagnosis of PTC and in turn improved clinical care in patients with limited sample availability or in samples with ...
Na Yu   +11 more
wiley   +1 more source

Absolute Bioavailability and Absorption, Distribution, Metabolism, and Excretion of [<sup>14</sup>C]Xevinapant, a Potent, Oral, Small-Molecule IAP Inhibitor. [PDF]

open access: yesClin Pharmacol Drug Dev
Menetrey A   +8 more
europepmc   +1 more source

Understanding Autistic Young Adults' Perceptions and Experiences of Traumatic and Stressful Events

open access: yesJournal of Clinical Psychology, Volume 81, Issue 6, Page 445-461, June 2025.
ABSTRACT Objectives The aim of this study was to explore how young autistic adults experience and respond to stressful life events, and the relationship between autistic characteristics and symptoms of stress associated with these events. Methods Using an exploratory sequential mixed‐methods approach, an online qualitative survey was first administered
Alliyza Lim, Robyn L. Young
wiley   +1 more source

Risk assessment of radionuclides in different environmental matrices in the State of Qatar, Arabian Gulf. [PDF]

open access: yesEnviron Geochem Health
Veerasingam S   +8 more
europepmc   +1 more source

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