Results 31 to 40 of about 11,440 (262)

Optmization of exposure parameters in digital mammography (CR) using figure of merit

Brazilian Journal of Radiation Sciences, 2021
A high diagnostic standard associated with the lowest radiation dose possible for the patient is the aim for a quality examination in mammography, this can be achieved through the Figure of Merit which is a parameter used for optimization in digital ...
Isabela Soares de Morais, Peterson Lima Squair, Maria do Socorro Nogueira Tavares   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Effects of oxidatively modified LDL on cholesterol esterification in cultured macrophages.

Journal of Lipid Research, 1990
Oxidative modification of low density lipoproteins (LDL) has been shown to cause accelerated degradation of LDL via the scavenger receptor pathway in cultured macrophages, and it has been proposed that this process might lead to cholesterol accumulation ...
HF Zhang, HJ Basra, UP Steinbrecher
doaj   +1 more source

Analysis of patients with prostate cancer care at a reference hospital in the state of Tocantins, suitable for brachytherapy

Brazilian Journal of Radiation Sciences, 2021
A observação e identificação de fatores preditivos de resultados e morbidade são essenciais na seleção ideal de pacientes que podem usar a braquiterapia como modalidade de tratamento para o câncer de próstata.
André de Souza Bezerra, Maria Elisa Chuery Martins Rostelato, Carlos Alberto Zeituni   +2 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Ways to reduce radioactivity accumulation in the kidney during targeted therapy using small molecules, peptides and antibody fragments

Сибирский онкологический журнал
Administration of pharmaceuticals containing radioactive isotopes and capable of specific binding to certain proteins is one of the approaches used in the treatment or diagnosis of malignant tumors.
K. O. Avrov, S. V. Shatik, M. P. Samoilovich   +2 more
doaj   +1 more source

Study of the relationship between mineralogical types and potential radon in rocks of the region of Serra do Gandarela – Quadrilátero Ferrífero-MG.

Brazilian Journal of Radiation Sciences, 2021
The Quadrilátero Ferrífero (QF) is one of the most well-known metallogenetic provinces in the world and has its geological context well studied since the end of the 17th century.
Natália Fonseca Taveira, Frederico Guimarães, Talita Santos, Francisco Rios, Mariza Franklin, Ariela Diniz, Aimoré Neto, Maria Ângela Menezes, Zildete Rocha   +8 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Calibration of Solid State Nuclear Track Detectors CR-39 for radon study in a high concentration underground mines

Brazilian Journal of Radiation Sciences, 2021
The Brazilian National Commission for Nuclear Energy (CNEN) establishes a reference level of 1000 Bq m-3 of radon concentration in underground mines. Solid State Nuclear Track Detectors – SSNTD is considered the main method of analysis in radon research.
Laura Takahashi, Talita Santos, Bárbara Correa, Rose Mary Pinheiro, Maria Ângela Menezes, Zildete Rocha   +5 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source