Results 51 to 60 of about 7,835 (150)

A2A Adenosine Receptor Agonists With Last‐Step Enzymatic 18F‐Labelling Potential (Fluorinase) for Positron Emission Tomography (PET)

European Journal of Organic Chemistry, Volume 29, Issue 5, 7 February 2026.
This study exploits the comparable binding tolerances between the fluorinase enzyme and the A2A adenosine receptor towards the development of novel C‐2 functionalised 5′‐fluorodeoxy‐adenosine (FDA)‐based agonists with enzymatic 18F‐labelling capability for positron emission tomography (PET).
Nicolas Charalambous, Carina Schleidt, Rongfang Liu, Laura H. Heitman, Sergio Dall’Angelo, David O’Hagan, Phillip T. Lowe   +6 more
wiley   +1 more source

Development and Kinetic Modeling of Continuous‐Flow Asymmetric Hydrogenation With Integrated Catalyst Recycling

ChemCatChem, Volume 18, Issue 3, 12 February 2026.
ABSTRACT In the development of economic competitive and sustainable pharmaceutical manufacturing with homogeneous catalysts, catalyst recovery is a key step toward efficient and scalable processes, as it directly impacts process efficiency and economic feasibility.
Maurice Moll, Thorsten Röder, Björn Wängler, Carmen Wängler, Alexander Fabricius, Nico Maier   +5 more
wiley   +1 more source

Exploring CPP Enhanced Hypoxia Targeting: An Approach Using Radiolabeled 2‐nitroimidazole TAT Conjugate

Drug Development Research, Volume 87, Issue 1, February 2026.
ABSTRACT Mediated by their protein transduction domain, cell‐penetrating peptides (CPPs) have been widely explored for facilitating intracellular delivery of drugs and small molecules. In this study, a radiolabeled, 2‐nitroimidazole conjugated TAT (TAT ‐ transactivator of transcription) peptide was prepared and evaluated for targeting tumor hypoxia ...
Sweety Mittal, Akanksha Jain, Ashwini Babu, Chandan Kumar, Madhava B. Mallia   +4 more
wiley   +1 more source

Synthesis and Application of [18F]Togni Reagent I: An Electrophilic 18F‐Labeled Trifluoromethylating Reagent for Positron Emission Tomography Tracer Synthesis

European Journal of Organic Chemistry, Volume 29, Issue 4, January 26, 2026.
Togni reagent I, one of the most used electrophilic trifluoromethylating reagents, has been radiolabeled with fluorine‐18 starting from the widely available fluoro‐benziodoxole and the [18F]Ruppert–Prakash reagent. To demonstrate the broad potential for late‐stage functionalization, aliphatic carboxylic acids were successfully converted into their 18F ...
Lizeth Y. F. Haveman, Albert D. Windhorst, Danielle J. Vugts   +2 more
wiley   +1 more source

18F‐Radiopharmaceutical Diversification Enabled by Deaminative Cross‐Electrophile Couplings

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
A general Ni‐mediated (C)sp2–(C)sp3 cross‐coupling expedites access to 18F‐radiopharmaceuticals, essential for positron emission tomography imaging and drug discovery. This late‐stage diversification approach was implemented across three user‐friendly automated protocols affording 18F‐radiotracers in sufficient quantities for imaging.
Isabella F. Ogilvy, Joseph Ford, Sebastiano Ortalli, Evelien Renders, Thomas R. Hayes, Shuanglong Liu, Inne Mortiers, Anastasia Nikolopoulou, Alexandre M. Sorlin, Andrés A. Trabanco, Matthew Tredwell, Peter J. J. A. Buijnsters, Rhys Salter, Véronique Gouverneur   +13 more
wiley   +1 more source

Preclinical comparison of four [18F, natGa]rhPSMA-7 isomers: influence of the stereoconfiguration on pharmacokinetics

EJNMMI Research, 2020
Introduction Radiohybrid (rh) ligands, a novel class of prostate-specific membrane antigen (PSMA)-targeted radiopharmaceuticals, can be labeled either with [18F]fluorine via isotopic exchange or with radiometals (such as [68Ga]Gallium, [177Lu]Lutetium ...
Alexander Wurzer, Mara Parzinger, Matthias Konrad, Roswitha Beck, Thomas Günther, Veronika Felber, Stefanie Färber, Daniel Di Carlo, Hans-Jürgen Wester   +8 more
doaj   +1 more source

Synthesis and Radiolabelling of DOTA-Linked Glutamine Analogues with 67,68Ga as Markers for Increased Glutamine Metabolism in Tumour Cells

Molecules, 2013
DOTA-linked glutamine analogues with a C6- alkyl and polyethyleneglycol (PEG) chain between the chelating group and the L-glutamine moiety were synthesised and labelled with 67,68Ga using established methods.
Ivan Greguric, Andrew G. Katsifis, Elisabeth Oehlke, Nigel A. Lengkeek, Nicholas R. Howell, Rachael K. Shepherd, Paul A. Pellegrini   +6 more
doaj   +1 more source

Bioorthogonal Chemistry in Biomolecule Quantification: A Review of Reactions and Strategies

Chemistry – A European Journal, Volume 32, Issue 1, 2 January 2026.
This review summarizes the application of catalyst‐free bioorthogonal reactions: Staudinger ligation, strain promoted azide alkyne cycloaddition, inverse electron‐demand Diels–Alder, and 2‐cyanobenzothiazole cysteine condensation in the semi‐quantitative and quantitative analysis of biomolecules.
Mingze Yang, Shiqi Wang
wiley   +1 more source

Molecular Imaging with 68Ga Radio-Nanomaterials: Shedding Light on Nanoparticles

Applied Sciences, 2018
The combination of radioisotopes and nanomaterials is creating a new library of tracers for molecular imaging, exploiting the sensitivity of nuclear imaging techniques and the size-dependent properties of nanomaterials. This new approach is expanding the
Irene Fernández-Barahona, María Muñoz-Hernando, Juan Pellico, Jesús Ruiz-Cabello, Fernando Herranz   +4 more
doaj   +1 more source

Ultrasensitive Ion‐Imprinted Detection System with Pore‐Depended Electrochemiluminescence Mechanism for Accurate and Rapid Monitoring of Cesium in the Environment

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study focuses on the rapid and accurate determination of cesium, a key radioactive contaminant attracting global attention, by creating an ultrasensitive pore‐dependent electrochemiluminescence detection system. It has been successfully applied in the determination of various kinds of environmental samples, exhibiting its significance in the ...
Ziyu Wang, Lei Fang, Jianing Zhao, Chengqi Li, Hebing Xie, Jian‐Bin Pan, Daoben Hua   +6 more
wiley   +1 more source