Results 51 to 60 of about 24,433 (235)

Learning Strategies from Nature's Blueprint to Cyclic Carbonate Synthesis

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
The development of sustainable synthetic methods for cyclic carbonates draws inspiration from nature, focusing on eco‐friendly processes and renewable resources like CO2 and biomass. This review explore various CO2 activation mechanisms, green chemistry principles, and green catalysts.
Erika Saccullo, Vincenzo Patamia, Chiara Zagni, Antonio Rescifina, Giuseppe Floresta   +4 more
wiley   +1 more source

First-in-Human PET Imaging of [18F]SDM-4MP3: A Cautionary Tale

Molecular Imaging, 2023
[18F]SynVesT-1 is a PET radiopharmaceutical that binds to the synaptic vesicle protein 2A (SV2A) and serves as a biomarker of synaptic density with widespread clinical research applications in psychiatry and neurodegeneration.
Kimberly L. Desmond, Anton Lindberg, Armando Garcia, Junchao Tong, Michael B. Harkness, Elena Dobrota, Kelly Smart, Carme Uribe, Jeffrey H. Meyer, Sylvain Houle, Antonio P. Strafella, Songye Li, Yiyun Huang, Neil Vasdev   +13 more
doaj   +1 more source

One-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents [PDF]

, 2017
An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described.
Luthra, Sajinder K., McRobbie, Graeme, Pimlott, Sally L., Sloan, Nikki L., Sutherland, Andrew   +4 more
core   +2 more sources

Phosphorus‐Structured Gel Electrolytes Enable Dual Protection for Thermal Runaway‐Resistant Lithium Metal Batteries

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
The PD‐VI GPE synthesized via in situ γ‐ray polymerization facilitates formation of a dense F/P‐rich SEI layer, enabling stable Li deposition while suppressing interfacial side reactions. The phosphorus‐containing framework enhances separator thermal stability and effectively mitigates O2 release from cathodes, demonstrating improved safety under the ...
Zeyu Zhang, Fan Jiang, Xibang Chen, Mingshu Xie, Sontong Zhang, Pengchen Zhao, Xiayu Zhu, Jintao Li, Jing Peng, Weibo Hua, Wenqi Huang, Jiuqiang Li, Xue Yang, Bin Liao, Le Yu, Maolin Zhai, Jingyi Qiu   +16 more
wiley   +1 more source

Development and Biological Evaluation of the First Highly Potent and Specific Benzamide-Based Radiotracer [¹⁸F]BA3 for Imaging of Histone Deacetylases 1 and 2 in Brain

Pharmaceuticals, 2022
The degree of acetylation of lysine residues on histones influences the accessibility of DNA and, furthermore, the gene expression. Histone deacetylases (HDACs) are overexpressed in various tumour diseases, resulting in the interest in HDAC inhibitors ...
Oliver Clauß, Linda Schäker-Hübner, Barbara Wenzel, Magali Toussaint, Winnie Deuther-Conrad, Daniel Gündel, Rodrigo Teodoro, Sladjana Dukić-Stefanović, Friedrich-Alexander Ludwig, Klaus Kopka, Peter Brust, Finn K. Hansen, Matthias Scheunemann   +12 more
doaj   +1 more source

A2A Adenosine Receptor Agonists With Last‐Step Enzymatic 18F‐Labelling Potential (Fluorinase) for Positron Emission Tomography (PET)

European Journal of Organic Chemistry, EarlyView.
This study exploits the comparable binding tolerances between the fluorinase enzyme and the A2A adenosine receptor towards the development of novel C‐2 functionalised 5′‐fluorodeoxy‐adenosine (FDA)‐based agonists with enzymatic 18F‐labelling capability for positron emission tomography (PET).
Nicolas Charalambous, Carina Schleidt, Rongfang Liu, Laura H. Heitman, Sergio Dall’Angelo, David O’Hagan, Phillip T. Lowe   +6 more
wiley   +1 more source

Synthesis and Radiolabelling of DOTA-Linked Glutamine Analogues with 67,68Ga as Markers for Increased Glutamine Metabolism in Tumour Cells

Molecules, 2013
DOTA-linked glutamine analogues with a C6- alkyl and polyethyleneglycol (PEG) chain between the chelating group and the L-glutamine moiety were synthesised and labelled with 67,68Ga using established methods.
Ivan Greguric, Andrew G. Katsifis, Elisabeth Oehlke, Nigel A. Lengkeek, Nicholas R. Howell, Rachael K. Shepherd, Paul A. Pellegrini   +6 more
doaj   +1 more source

Recent Developments in Carbon-11 Chemistry and Applications for First-In-Human PET Studies

Molecules, 2023
Positron emission tomography (PET) is a molecular imaging technique that makes use of radiolabelled molecules for in vivo evaluation. Carbon-11 is a frequently used radionuclide for the labelling of small molecule PET tracers and can be incorporated into
Anna Pees, Melissa Chassé, Anton Lindberg, Neil Vasdev   +3 more
doaj   +1 more source

Rapid, efficient, and economical synthesis of PET tracers in a droplet microreactor: application to O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET). [PDF]

, 2019
BackgroundConventional scale production of small batches of PET tracers (e.g. for preclinical imaging) is an inefficient use of resources. Using O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET), we demonstrate that simple microvolume radiosynthesis ...
Chen, Bao Ying, Clark, Peter M, Fong, Kelly Mun-Ming, Lisova, Ksenia, van Dam, R Michael, Wang, Jia   +5 more
core   +1 more source

Anion emission from water molecules colliding with positive ions: Identification of binary and many-body processes

, 2015
It is shown that negative ions are ejected from gas-phase water molecules when bombarded with positive ions at keV energies typical of solar-wind velocities.
Bene, E., Chesnel, J. -Y., Herczku, P., Huber, B. A., Juhász, Z., Kovács, S. T. S., Lattouf, E., Méry, A., Poully, J. -C., Rangama, J., Sulik, B., Tanis, J. A.   +11 more
core   +3 more sources