Results 81 to 90 of about 23,247 (237)

Development of Carbon‐11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma‐1 Receptor Imaging

open access: yesAdvanced Science, Volume 12, Issue 21, June 5, 2025.
Novel carbon‐11 labeled pyrimidine derivatives are developed as PET imaging probes for visualizing sigma‐1 receptors in the brain. [11C]CNY‐01 demonstrates superior brain uptake and binding specificity in both rodents and non‐human primates. The study reveals decreased sigma‐1 receptor expression in Alzheimer's disease, offering a promising tool for ...
Ping Bai   +12 more
wiley   +1 more source

Anion emission from water molecules colliding with positive ions: Identification of binary and many-body processes

open access: yes, 2015
It is shown that negative ions are ejected from gas-phase water molecules when bombarded with positive ions at keV energies typical of solar-wind velocities.
Bene, E.   +11 more
core   +3 more sources

Production Of 11C‐Labeled Amides Via “In‐Loop” 11C‐Carbonylation

open access: yesAsian Journal of Organic Chemistry, Volume 14, Issue 6, June 2025.
The current work utilizes carbon‐11 labelled aroyl dimethylaminopyridinium salts in a two‐step in‐loop carbonylative cross‐coupling reaction of aryl halides with [¹¹C]CO yielding a diverse range of carbon‐11 labelled primary benzamides with good to excellent yields.
Tanpreet Kaur   +3 more
wiley   +1 more source

Synthesis and in vitro and in vivo evaluation of urea-based PSMA inhibitors with increased lipophilicity

open access: yesEJNMMI Research, 2018
Background Several radiolabeled prostate-specific membrane antigen (PSMA) inhibitors based on the lysine-urea-glutamate (KuE) motif as the pharmacophore proved to be suitable tools for PET/SPECT imaging of the PSMA expression in prostate cancer patients.
Martina Wirtz   +6 more
doaj   +1 more source

Examining the association between synaptic density and neurofibrillary tau among cognitively impaired and unimpaired older adults with and without Alzheimer's disease pathology

open access: yesAlzheimer's &Dementia, Volume 21, Issue 6, June 2025.
Abstract INTRODUCTION Synapse loss is a key driver of cognitive decline in Alzheimer's disease (AD), yet its direct relationship with neurofibrillary tau tangle (NFT) burden remains unclear. This study leveraged positron emission tomography (PET) imaging to investigate the link between NFT accumulation and synaptic density in older adults with and ...
Alexandra H. DiFilippo   +18 more
wiley   +1 more source

Techniques of Radiochemistry [PDF]

open access: yesNature, 1953
Modern Radiochemical Practice By Dr. G. B. Cook and Dr. J. F. Duncan. Pp. xx + 408 + 4 plates. (Oxford: Clarendon Press; London: Oxford University Press, 1952.) 42s. net.
openaire   +1 more source

Analyses of Apollo 11 and 12 rocks and soils by neutron activation [PDF]

open access: yes
Neutron activation analysis of Apollo 11 and 12 rocks and soils, and X ray fluorescence and radiochemistry ...
Kharkar, D. P., Turekian, K. K.
core   +1 more source

Spartan Daily, September 25, 1990 [PDF]

open access: yes, 1990
Volume 95, Issue 18https://scholarworks.sjsu.edu/spartandaily/8018/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +2 more sources

A brief history of Aβ imaging

open access: yesAlzheimer's &Dementia, Volume 21, Issue 5, May 2025.
Abstract β‐Amyloid (Αβ) imaging revolutionized the in vivo assessment of Alzheimer's disease (AD) Αβ pathology and its changes over time, increasing our insights into Aβ deposition in the brain by providing highly accurate, reliable, and reproducible quantitative statements of regional and global Aβ burden in the brain, proving essential for the ...
Ann D. Cohen, Victor L. Villemagne
wiley   +1 more source

Application of Palladium-Mediated 18F-Fluorination to PET Radiotracer Development: Overcoming Hurdles to Translation [PDF]

open access: yes, 2013
New chemistry methods for the synthesis of radiolabeled small molecules have the potential to impact clinical positron emission tomography (PET) imaging, if they can be successfully translated.
Carlin, Stephen M.   +7 more
core   +3 more sources

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