Results 161 to 170 of about 27,100 (214)

Venous sinus stenting for pulsatile tinnitus secondary to venous sinus stenosis: a dual-center retrospective cohort study. [PDF]

Neurosurg Rev
Elfadle AA, Hemeda MS, Elassy MAE, Salah W, Nada A, Zaki MRAEA, Elghareeb M.   +6 more
europepmc   +1 more source

Non‐Invasive Assessment of Perineural Invasion Density: A Novel Marker for Prognosis and Treatment Stratification in Prostate Cancer

Advanced Science, EarlyView.
This study establishes perineural invasion density (PNID) as a superior prognostic marker in prostate cancer, outperforming conventional perineural invasion in predicting biochemical recurrence and radiographic progression. Concurrent β–blocker use is associated with favorable outcomes exclusively in High–PNID patients. An MRI–based deep learning model
Bohao Liu, Long Zhang, Weian Zhu, Meng Yang, Xiang Liu, Xiaoyang Li, Peng Qin, Zhengxu Lin, Qian Cai, Jiayu Zheng, Xiao Zhao, Chen Zou, Xuan Wen, Longhao Xu, Daqin Wu, Lin Zhang, Cuilian Zhang, Kaiwen Li, Chunhui Wang, Wenlong Zhong, Yun Luo   +20 more
wiley   +1 more source

Morphologic variations of the sigmoid sinus on computed tomography: a classification-based study. [PDF]

Surg Radiol Anat
Medişoğlu MS, Öçbe M.
europepmc   +1 more source

Lactate Homeostasis Disruption Potentiates TACE‐Immunotherapy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Lactate homeostasis is disrupted through spatially coordinated extracellular neutralization and intracellular acidification, triggering calcium overload, mitochondrial dysfunction, and immunogenic cell death. This metabolic reprogramming alleviates the immunosuppressive tumor microenvironment and enhances immune checkpoint blockade, providing a ...
Minjiang Chen, Xiaoxiao Chen, Baozhu Yang, Hui Xu, Xueting Sun, Hongkai Qi, Huilin Hu, Ronghua Wu, Fengkai Qiu, Bing Wu, Yu Luo, Gaofeng Shu, Jiansong Ji   +12 more
wiley   +1 more source

Amcinonide Exhibits Antitumor Effects in Radioresistant Colorectal Cancer Through the circRNF10/miR‐296‐5p/Snail Axis

Advanced Science, EarlyView.
Amcinonide (AMC), the FDA‐approved corticosteroid, was identified as a repurposed agent for radiation‐resistant colorectal cancer. AMC suppresses radiation‐induced epithelial–mesenchymal transition, migration, and invasion via the circRNF10/miR‐296‐5p/Snail axis.
Hyun Jeong Seok, Dong Hyeon Lee, Junhye Kwon, Ui Sup Shin, In Hwa Bae   +4 more
wiley   +1 more source

Erratum: Evaluating the Accuracy and Diagnostic Reasoning of Multimodal Large Language Models in Interpreting Neuroradiology Cases From <i>RadioGraphics</i>. [PDF]

Korean J Radiol
Suh PS, Ko JS, Shim WH, Heo H, Woo CY, Park H, Suh CH.   +6 more
europepmc   +1 more source

A Multi‐Structural Radiomic Digital Phenotyping Framework for Deciphering Preclinical Evolution of Degenerative Meniscal Tears

Advanced Science, EarlyView.
Subclinical matrix disruption precedes degenerative meniscal tears across the knee joint. A spatial compartmental radiomics model utilizing 3D‐DESS MRI captures early osteochondral destabilization, accurately predicting incident tears up to four years pre‐collapse. Feature attributions uncover coordinated chondral and osseous alterations, advancing non‐
Shengfa Li, Hao Liu, Yanbin Zhu, Hang Zhang, Qifeng Tao, Wenbo Zhao, Xin Miao, Shanshan Yang, Tianyu Chen, David Hunter, Changhai Ding, Ting Wang, Juan Wang, Wei Chen   +13 more
wiley   +1 more source

Patient Centring in CT: An International Survey of Clinical Practice and Future Directions. [PDF]

J Med Radiat Sci
Hadi YH, Bani-Ahmad M, Moore N, Clark KR, Al-Hayek Y, Albeshan SM, Alghamdi SB, Precht H, England A, McEntee M.   +9 more
europepmc   +1 more source

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu, Sheng‐Jie Chang, Xiao‐Wei Liu, Shu‐Bao Zhang, Ying‐Jie Wang, Shan‐Jin Wang   +5 more
wiley   +1 more source