Results 31 to 40 of about 7,841,761 (275)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Noninvasive NMR/MRS Metabolic Parameters to Evaluate Metabolic Syndrome in Rats

Diagnostics, 2022
(1) Background: Ectopic fat deposition and its effects, metabolic syndrome, have been significantly correlated to lifestyle and caloric consumption. There is no specific noninvasive evaluation tool being used in order to establish clinical markers for ...
Khin Thandar Htun, Krit Jaikumkao, Jie Pan, Aye Thidar Moe Moe, Nuttawadee Intachai, Sasivimon Promsan, Anusorn Lungkaphin, Monruedee Tapanya, Duanghathai Pasanta, Montree Tungjai, Siriprapa Kaewjaeng, Hong Joo Kim, Jakrapong Kaewkhao, Christopher Lai, Suchart Kothan   +14 more
doaj   +1 more source

Low-Dose Fluoroscopy Protocol for Diagnostic Cerebral Angiography [PDF]

Neurointervention, 2020
Purpose We applied a low-dose fluoroscopic protocol in routine diagnostic cerebral angiography and evaluated the feasibility of the protocol. Materials and Methods We retrospectively reviewed a total of 60 patients who underwent diagnostic cerebral ...
Yunsun Song, Seongsik Han, Byung Jun Kim, Seong Heum Oh, Jin Su Kim, Tae Il Kim, Deok Hee Lee   +6 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Assessments of Medical Student’s Knowledge About Radiation Protection and Different Imaging Modalities in Jeddah, Saudi Arabia

International Journal of Biomedical Imaging
Conclusions: The assessments of medical students’ knowledge regarding radiation exposure in diagnostic modalities reveal a low level of confidence in their knowledge of ionizing radiation dose parameters. Furthermore, the mean scores on overall knowledge
Raghad Aljondi, Rahaf Alem, Rowa Aljondi, Abdulrahman Tajaldeen, Salem Saeed Alghamdi, Mohammed Majdi Toras   +5 more
doaj   +1 more source

Radiological Technology for Targeted Radionuclide Therapy

Japanese Journal of Radiological Technology, 2020
Targeted radioisotope therapy (TRT) is a radiotherapy using radioisotope or drug incorporating it and has been used as a treatment for selectively irradiating cancer cells. In recent years, interest in TRT has increased due to improvements in radionuclide production technology, development of new drugs and imaging modalities, and improvements in ...
Kohei, Hanaoka, Noriaki, Miyaji, Hiroto, Yoneyama, Matsuyoshi, Ogawa, Takamasa, Maeda, Kenta, Sakaguchi, Takashi, Iimori, Hiroyuki, Tsushima   +7 more
openaire   +3 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Iron–quercetin complex reprograms tumor-associated macrophages toward M1 phenotype and enables MRI tracking in ex vivo tumor-mimicking spheroids

Cancer Nanotechnology
Background Tumor-associated macrophages (TAMs) frequently adopt an M2-like, immunosuppressive state that promotes tumor growth and therapy resistance. Reprogramming TAMs toward a pro-inflammatory M1 phenotype is a promising strategy to remodel the tumor ...
Nathupakorn Dechsupa, Phattarawadee Innuan, Waqas Ihsan, Cherdphong Korbuakesorn, Kawinna Siri, Pimwipa Tepinta, Pitchayapon Ariyawatkul, Rattawish Khamphorn, Saran Phohiran, Chengli Wen, Witida Laopajon, Jiraporn Kantapan   +11 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source