Results 131 to 140 of about 179,985 (317)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Patient Agency in Imaging: Radiologists’ Insights

Objectives There is a notable rise in patient‐initiated imaging requests, with one possible reason being the increased availability of online health information.
Lizzie De Silva, Peter Kench, Melissa Baysari, Melanie Keep, Jillian Clarke   +4 more
core   +1 more source

Egocentric professional network of four different radiologists.

, 2016
Upper Row: radiologists with high degree centrality, relatively high effective size, low constraint, low hierarchy and high performance (JAFROC FOM = .91 (upper left) and .91 (upper right)).
Liaquat Hossain (287458), Patrick Brennan (2503681), Robert Heard (716521), Seyedamir Tavakoli Taba (2503612), Sarah Lewis (70866), Warwick Lee (2503684)   +5 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Radiologists' Training, Experience, and Attitudes About Elder Abuse Detection

, 2016
Elder abuse is underrecognized, and identification of subtle cases requires a high index of suspicion among all health care providers. Because many geriatric injury victims undergo radiographic imaging, diagnostic radiologists may be well positioned to ...
Bloemen, Elizabeth M, Thomas J. McCarthy, Sanchez, Allen M, McCarthy, Thomas J, Allen M. Sanchez, Lachs, Mark S, Veronica M. LoFaso, Tony Rosen, Jasmin Harpe, Kieran Murphy, Mark S. Lachs, Kevin W. Mennitt, Harpe, Jasmin, LoFaso, Veronica M, Mennitt, Kevin W, Murphy, Kieran, Neal Flomenbaum, Flomenbaum, Neal, Elizabeth M. Bloemen, Rosen, Tony, Nicola, Refky, Refky Nicola   +21 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Radiologists and algorithm AUC with CIs.

, 2018
Radiologists and algorithm AUC with CIs.
Evan J. Zucker (5993063), Andrew Y. Ng (5403176), Tony Duan (5993030), Katie Shpanskaya (5993045), Kaylie Zhu (5993021), David A. Mong (5993057), Kristen W. Yeom (753979), Daisy Ding (5993033), Aarti Bagul (5993036), Bhavik N. Patel (5993042), Safwan S. Halabi (5993060), Hershel Mehta (5993027), Curtis P. Langlotz (5993039), Timothy J. Amrhein (5993054), Pranav Rajpurkar (5993015), Francis G. Blankenberg (5993048), Jeremy Irvin (5993018), Robyn L. Ball (3682054), Jayne Seekins (5993051), Brandon Yang (5993024), Matthew P. Lungren (4536982)   +20 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source