Results 161 to 170 of about 379,277 (342)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Interobserver Variability in Hysterosalpingography Interpretation: Radiologists vs Gynecologists

International Journal of Women's Health
Ceyda Karadag,1 Cemil Gurses,2 Adnan Kabaalioglu,3 Bengi Gurses,3 İsmail Güzelmansur,4 Turgay Daplan,4 Arzu Turan,5 Hakan Artas,6 Sadan Tutus,7 Safak Olgan,8 İlknur Col Madendag,7 Ahmet Demir,9 Sezcan Mumusoglu,10 Yunus Aydin,11 Emre ...
Karadag C, Gurses C, Kabaalioglu A, Gurses B, Güzelmansur İ, Daplan T, Turan A, Artas H, Tutus S, Olgan S, Col Madendag İ, Demir A, Mumusoglu S, Aydin Y, Pabuccu EG   +14 more
doaj  

Enhancing radiology workflows through collaborative AI-assisted chest X-ray reporting using large vision-language models: a proof-of-concept study. [PDF]

Insights Imaging
Pellegrini C, Özsoy E, Gassert FT, Marka AW, Strenzke M, Keicher M, Makowski MR, Navab N.   +7 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Are you always working in the dark? The impact of limited daylight exposure on radiologists' health. [PDF]

Insights Imaging
Landsmann A, Rovetto C, Knöpfli F, Kubik-Huch RA.   +3 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The effect of medical explanations from large language models on diagnostic accuracy in radiology. [PDF]

NPJ Digit Med
Spitzer P, Hendriks D, Rudolph J, Schlaeger S, Ricke J, Kühl N, Hoppe BF, Feuerriegel S.   +7 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

SCAR-Net-assisted ultrasound diagnosis of postoperative scars and recurrent lesions in breast cancer. [PDF]

iScience
Feng N, Zhao S, Lei Z, Yi D, Yao J, Zhang X, Li X, Zou W, Zhang J, Chen L, Yang C, Xu D, Wu Y.   +12 more
europepmc   +1 more source