Results 221 to 230 of about 240,436 (283)

AI in Prostate MRI: A Task-Based Review. [PDF]

J Korean Soc Radiol
Choi MH.
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A clinically validated 3D deep learning approach for quantifying vascular invasion in pancreatic cancer. [PDF]

NPJ Digit Med
Zhang Y, Zhang H, Yang Y, Wu C, Zhang L, Xia W, Wang X, Zhang X, Cao L, Liu M, Zhang J, Yan F, Shen B, Wen N.   +13 more
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Performance of ChatGPT-4o, Claude 3 Opus, and DeepSeek-R1 in BI-RADS Category 4 Classification and Malignancy Prediction From Mammography Reports: Retrospective Diagnostic Study.

JMIR Med Inform
Dai X, Ke M, Xie D, Mei M, Wei S, Dai Y, Yan R.   +6 more
europepmc   +1 more source

Radiology Staff Experiences With Integrating Artificial Intelligence Into Radiology Practice in a Swedish Hospital: Qualitative Case Study. [PDF]

JMIR Form Res
Nilsen P, Svedberg P, Larsson I, Petersson L, Nygren J, Steerling E, Neher M.   +6 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Direct deep learning analysis of three-dimensional automated breast ultrasound videos with reading mode optimization for breast cancer diagnosis. [PDF]

Ultrasonography
Guo Y, Wang C, Liu Y, Pang Y, Ge R, Li W, Liu L, Zhang Q, Chen L.   +8 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Evolving Landscape of Cardiac Radiology in Asia. [PDF]

Korean J Radiol
Lee J.
europepmc   +1 more source