Results 81 to 90 of about 179,985 (317)

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Artificial intelligence–assisted detection of challenging ischemic stroke on diffusion-weighted imaging: a reader study

Frontiers in Neurology
Background and purposeTo evaluate the effect of artificial intelligence (AI) assistance on the diagnostic performance of human readers for detecting challenging acute ischemic stroke (AIS) lesions on diffusion-weighted MRI.MethodsThis retrospective ...
Younbeom Jeong, Wi-Sun Ryu, Beom Joon Kim, Byung Se Choi, Jae Hyoung Kim, Leonard Sunwoo, Leonard Sunwoo   +6 more
doaj   +1 more source

A radiologist’s perspective [PDF]

CJEM, 1999
Focused abdominal sonography in trauma (FAST) has in many centres replaced the diagnostic peritoneal lavage (DPL) for the early assessment of acute blunt abdominal trauma. In many cases a negative FAST obviates the need for further imaging and intervention.
openaire   +2 more sources

Observer agreement in the reporting of knee and lumbar spine Magnetic Resonance (MR) Imaging examinations: selectively trained MR radiographers and consultant radiologists compared with an index radiologist

, 2013
Purpose: To assess agreement between trained radiographers and consultant radiologists compared withan index radiologist when reporting on magnetic resonance imaging (MRI) examinations of the knee andlumbar spine and to examine the subsequent effect of ...
Gibbon, A., Brealey, S., Piper, K., Bland, M., Warren, D., Highland, A., Jenkins, N., King, D., Caddick, J., Petty, D.   +9 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Visual Search Performance and Strategy for Three-Dimensional Visualization Systems: Impact of Radiologist Experience

Applied Sciences, 2019
The visual search performance of radiologists is systematically challenged due to the use of flat-panel displays when viewing multi-slice images. Three-dimensional visualization of information is expected to facilitate visual search for radiologists ...
Tatjana Pladere, Mara Delesa-Velina, Viktorija Andriksone, Reinis Pitura, Karola Panke, Gunta Krumina   +5 more
doaj   +1 more source

Agreement in neonatal x-ray interpretation: a comparison between consultant paediatric radiologists and a reporting radiographer

, 2014
X-rays are frequently used by clinicians to aid in patient diagnosis and management; infants which require specialised neonatal care are no exception.
Aladangady, N., Iliadis, K., Prakash, R., Piper, K., Woznitza, N., Santos, R.   +5 more
core