Results 211 to 220 of about 131,276 (280)

The origin, evolution and life cycle of rock art shelters in the Kimberley Basin of NW Australia

open access: yesEarth Surface Processes and Landforms, Volume 50, Issue 9, July 2025.
Sandstone rock shelters hosting abundant rock art in northwestern Australia evolve by undermining through recession of a weak layer, leading to progressive enlargement by bedding slab falls from the ceiling, creating new surfaces for rock paintings in the process. Eventually, continued undermining due to ongoing failure of the lower weak layer leads to
Andrew Gleadow   +7 more
wiley   +1 more source

124I‐labelled BMSC‐Derived Extracellular Vesicles Deliver CRISPR/Cas9 Ribonucleoproteins With a GFP‐Reporter System to Inhibit Osteosarcoma Proliferation and Metastasis

open access: yesJournal of Extracellular Vesicles, Volume 14, Issue 7, July 2025.
The fluorescence‐based Cas9 editing efficiency reporter system confirmed in vitro gene‐editing efficacy, while the radionuclide‐labelled BMSC‐derived EV delivery system demonstrated targeted in vivo distribution through radiolabel tracking. Following the validation of Cas9 RNP delivery specificity via dual‐modal imaging, subsequent mechanistic studies ...
Yujie Pan   +11 more
wiley   +1 more source

Hydroclimate variability in the eastern Kimberley, Australia, since the last deglaciation

open access: yesJournal of Quaternary Science, Volume 40, Issue 5, Page 893-912, July 2025.
ABSTRACT The climate of the Kimberley region in tropical northwest Australia is dominated by the Indo‐Australian summer monsoon (IASM). Understanding of the palaeoclimate since the Last Glacial Maximum in this region, which is well placed to record IASM variations, is currently based on few records.
Teresa Dixon   +8 more
wiley   +1 more source

The lowermost last‐glacial equilibrium line altitude in the Taiwanese Central Mountain Range and its implications for the palaeoclimate and the tropospheric moisture transport in East Asia

open access: yesJournal of Quaternary Science, Volume 40, Issue 5, Page 831-846, July 2025.
ABSTRACT The high mountains of Taiwan provide a unique location for Quaternary palaeoclimate research in East Asia and the north‐western Pacific. This study applies geomorphological field mapping and rock surface exposure dating with paired (10Be/26Al) in situ‐produced terrestrial cosmogenic nuclides to identify and date glacial landforms and boulders ...
Robert Hebenstreit   +2 more
wiley   +1 more source

Cancer‐Associated Fibroblasts: Heterogeneity, Cancer Pathogenesis, and Therapeutic Targets

open access: yesMedComm, Volume 6, Issue 7, July 2025.
Cancer‐associated fibroblasts (CAFs) arise from normal fibroblasts in response to various tumor microenvironmental signals, including cytokines such as TGF‐β and IL‐6, paracrine factors like PDGFs, Notch signaling, extracellular vesicles, as well as aging, inflammation, hypoxia, oxidative stress, and increased extracellular matrix (ECM) stiffness. Upon
Yutao Li   +6 more
wiley   +1 more source

Instantaneous in vivo distal edge verification in intensity‐modulated proton therapy by means of PET imaging

open access: yesMedical Physics, Volume 52, Issue 7, July 2025.
Abstract Background Intensity‐modulated proton therapy (IMPT) holds promise for improving outcomes in head‐and‐neck cancer (HNC) patients by enhancing organ‐at‐risk (OAR) sparing. A key challenge in IMPT is ensuring an accurate dose delivery at the distal edge of the tumor, where the steep dose gradients make treatment precision highly sensitive to ...
Brian Zapien‐Campos   +5 more
wiley   +1 more source

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