Results 51 to 60 of about 133,815 (258)
Scintigraphic assessment of bone status at one year following hip resurfacing : comparison of two surgical approaches using SPECT-CT scan [PDF]
, 2012 Objectives: To study the vascularity and bone metabolism of the femoral head/neck following hip resurfacing arthroplasty, and to use these results to compare the posterior and the trochanteric-flip approaches.
Amarasekera HW +31 more
core +1 more source
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
Imaging using radiolabelled targeted proteins: radioimmunodetection and beyond
EJNMMI Radiopharmacy and Chemistry, 2020 The use of radiolabelled antibodies was proposed in 1970s for staging of malignant tumours. Intensive research established chemistry for radiolabelling of proteins and understanding of factors determining biodistribution and targeting properties. The use
Javad Garousi +3 more
doaj +1 more source
Advanced Science, EarlyView.Monoclonal antibodies are powerful anticancer therapeutics targeting tumor‐associated antigens. Mass spectrometry enables precise and accurate quantification of mAbs in tumor plasma and healthy organs. Unlike ligand binding assay and radioactivity, mass spectrometry does not suffer from matrix effects and labelling artefacts while facilitating method ...
Domenico Ravazza +9 more
wiley +1 more source
Evaluation of radiological and clinical efficacy of ^{90}Y-DOTATATE} therapy in patients with progressive metastatic midgut neuroendocrine carcinomas [PDF]
, 2009 Background: To evaluate the radiological and clinical therapeutic effectiveness of ^{90}Y-octreotate [DOTATATE] inpatients with progressive somatostatin receptor-positive midgut neuroendocrine carcinomas (GEPNETs).
Buscombe, John R. +7 more
core
Numerical simulation of radionuclides migration in the far field of a geological repository [PDF]
, 2015 Safety conditions associated with geological repositories must be guaranteed also in the case of radionuclides migrating from the near field to the far field of a geological repository and to the external environment.
Cinzia, Miracapillo, Ferroni, Luisa
core +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Radiotheranostic Agents in Hematological Malignancies
Frontiers in Immunology, 2022 Radioimmunotherapy (RIT) is a cancer treatment that combines radiation therapy with tumor-directed monoclonal antibodies (Abs). Although RIT had been introduced for the treatment of CD20 positive non-Hodgkin lymphoma decades ago, it never found a broad ...
Jo Caers +15 more
doaj +1 more source
Dynamic Cell Imaging in PET with Optimal Transport Regularization
, 2019 We propose a novel dynamic image reconstruction method from PET listmode data that could be particularly suited to tracking single or small numbers of cells.
Schmitzer, Bernhard +2 more
core +1 more source
, 1999 Radionuclides with half-lives ranging from some years to billions of years presumably synthesized outside of the solar system are now recorded in ``live'' or ``fossil'' form in various types of materials, like meteorites or the galactic cosmic rays. They
Arnould, Marcel, Prantzos, Nikos
core +3 more sources