Dynamic Cell Imaging in PET with Optimal Transport Regularization [PDF]
We propose a novel dynamic image reconstruction method from PET listmode data that could be particularly suited to tracking single or small numbers of cells. In contrast to conventional PET reconstruction our method combines the information from all detected events not only to reconstruct the dynamic evolution of the radionuclide distribution, but also
arxiv +1 more source
155Tb production by cyclotrons: what level of 155Gd enrichment allows clinical applications? [PDF]
BACKGROUND: 155Tb represents a potentially useful radionuclide for diagnostic medical applications, but its production remains a challenging problem. A recent experimental campaign, conducted with low-energy proton beams impinging on a 155Gd target with 91.9% enrichment, demonstrated a significant co-production of 156gTb, a contaminant of great concern
arxiv
Visualization of radiotracers for SPECT imaging using a Timepix detector with a coded aperture [PDF]
The work shows the ability to visualize radiotracers used in SPECT with a system based on a coded aperture mask and a hybrid pixel Timepix detector with the CdTe sensor. Characterization of the system using X-rays and radioactive sources confirms that the spatial resolution of less than 1 mm with a field of view 3 cm x 3 cm can be achieved. The results
arxiv +1 more source
Radionuclide Imaging of Myocardial Metabolism [PDF]
Cardiac health is dependent on the heart’s ability to utilize different substrates to support overall oxidative metabolism to generate ATP. Indeed, a loss in plasticity in substrate preference is characteristic of a variety cardiac diseases such as diabetic heart disease, in which fatty acid metabolism predominates, and dilated cardiomyopathy, in which
Robert J. Gropler, Linda R. Peterson
openaire +2 more sources
Visualization of the Spiral Ganglion Neuron in Vivo Using a Novel 177Lu Nuclear Molecule Label
The study developed and validated a radionuclide‐labeled anti‐VGLUT1 antibody probe for the first nuclear imaging of cochlear spiral ganglion neurons (SGNs) in vivo. This approach may provide aid in screening candidates suitable for CI surgery by quantifying the number of surviving SGNs, and predicting the potential for postoperative hearing ...
Chenyang Kong+11 more
wiley +1 more source
Comparison of technetium-99m IgG with technetium-99m red blood cells labeling in cardiac blood-pool scintigraphy: A preliminary study [PDF]
This first clinical prospective study was conducted to use of technetium-99m immunoglobulin G (99mTc-IgG) as compared with autologous 99mTc-red blood cells (RBC) in gated blood pool ventriculography.
Amini, A.+7 more
core
The use of radiocobalt as a label improves imaging of EGFR using DOTA-conjugated Affibody molecule
Several anti-cancer therapies target the epidermal growth factor receptor (EGFR). Radionuclide imaging of EGFR expression in tumours may aid in selection of optimal cancer therapy.
Javad Garousi+10 more
doaj +1 more source
Diagram illustrating the binding methods of NPs and biological barriers. The biological carrier‐mediated nanomedicine hitchhiking strategy (BCM‐NHS) utilizes two distinct techniques: the surface‐based “Backpack” method, which relies on ligand‐receptor binding, covalent conjugation, and non‐covalent binding, and the encapsulated “Trojan horse” approach,
Yuyan Zhou+17 more
wiley +1 more source
Hyperthyroidism in cats, part II : scintigraphic diagnosis and radioiodine treatment [PDF]
In the second part of this review article, the diagnostic aspects of thyroid scintigraphy are discussed, with major emphasis on hyperthyroidism, followed by an overview of radioiodine ...
Daminet, Sylvie+4 more
core +1 more source
Internal radiation dose assessment of radiopharmaceuticals prepared with cyclotron-produced 99m Tc [PDF]
Technetium-99m (99m Tc) is the radioisotope most widely used in diagnostic nuclear medicine. It is readily available from 99 Mo/99m Tc generators as the \u3b2- decay product of the 99 Mo (T\ubd =66 h) parent nuclide.
Bello, Michele+9 more
core +1 more source