Results 121 to 130 of about 29,053 (244)

124I‐labelled BMSC‐Derived Extracellular Vesicles Deliver CRISPR/Cas9 Ribonucleoproteins With a GFP‐Reporter System to Inhibit Osteosarcoma Proliferation and Metastasis

Journal of Extracellular Vesicles, Volume 14, Issue 7, July 2025.
The fluorescence‐based Cas9 editing efficiency reporter system confirmed in vitro gene‐editing efficacy, while the radionuclide‐labelled BMSC‐derived EV delivery system demonstrated targeted in vivo distribution through radiolabel tracking. Following the validation of Cas9 RNP delivery specificity via dual‐modal imaging, subsequent mechanistic studies ...
Yujie Pan, Xianteng Yang, Zhirui Zeng, Futao Liu, Jin Luo, Mao Shen, Wei Zhou, Jianyang Li, Guangfu Jiang, Li Sun, Haifeng Huang, Runsang Pan   +11 more
wiley   +1 more source

Navigating care: understanding cancer patients' experiences with systemic radionuclide therapy. [PDF]

Support Care Cancer
Starkbaum J, Thircuir S, Winkler F, Griessler E.   +3 more
europepmc   +2 more sources

Comparative somatostatin receptor scintigraphy using In-111-DOTA-lanreotide and In-111-DOTA-Tyr3-octreotide versus F-18-FDG-PET for evaluation of somatostatin receptor-mediated radionuclide therapy

, 2001
Irene Virgolini, Pallavi Patri, C. Novotny, Tatjana Traub‐Weidinger, M. Leimer, Barbara Füger, Shuren Li, P. Angelberger, Markus Raderer, S. Wogritsch, Amir Kurtaran, Kurt Kletter, Robert Dudczak   +12 more
openalex   +1 more source

Whole-Body Dosimetry for Individualized Treatment Planning of ¹³¹I-MIBG Radionuclide Therapy for Neuroblastoma [PDF]

, 2009
Susan Buckley, Sarah Chittenden, Frank Saran, Simon Meller, Glenn Flux   +4 more
openalex   +1 more source

Cancer‐Associated Fibroblasts: Heterogeneity, Cancer Pathogenesis, and Therapeutic Targets

MedComm, Volume 6, Issue 7, July 2025.
Cancer‐associated fibroblasts (CAFs) arise from normal fibroblasts in response to various tumor microenvironmental signals, including cytokines such as TGF‐β and IL‐6, paracrine factors like PDGFs, Notch signaling, extracellular vesicles, as well as aging, inflammation, hypoxia, oxidative stress, and increased extracellular matrix (ECM) stiffness. Upon
Yutao Li, Qingyun Liu, Xilin Jing, Yuqi Wang, Xiaohua Jia, Xing Yang, Kezhong Chen   +6 more
wiley   +1 more source

Targeted Radionuclide Therapy Using a Wnt-Targeted Replicating Adenovirus Encoding the Na/I Symporter [PDF]

, 2009
Inge Peerlinck, Andrew Merron, Patrick Baril, Sophie Conchon, Pilar Martín‐Duque, Cécilia Hindorf, Jerome Burnet, Miguel Quintanilla, Mohan Hingorani, Richard Iggo, Nicholas R. Lemoine, Kevin J. Harrington, Georges Vassaux   +12 more
openalex   +1 more source

Instantaneous in vivo distal edge verification in intensity‐modulated proton therapy by means of PET imaging

Medical Physics, Volume 52, Issue 7, July 2025.
Abstract Background Intensity‐modulated proton therapy (IMPT) holds promise for improving outcomes in head‐and‐neck cancer (HNC) patients by enhancing organ‐at‐risk (OAR) sparing. A key challenge in IMPT is ensuring an accurate dose delivery at the distal edge of the tumor, where the steep dose gradients make treatment precision highly sensitive to ...
Brian Zapien‐Campos, Zahra Ahmadi Ganjeh, Giuliano Perotti‐Bernardini, Jeffrey Free, Stefan Both, Peter Dendooven   +5 more
wiley   +1 more source

Reference datasets for commissioning of model‐based dose calculation algorithms for electronic brachytherapy

Medical Physics, Volume 52, Issue 7, July 2025.
Abstract Purpose This work provides the first two clinical test cases for commissioning electronic brachytherapy (eBT) model‐based dose calculation algorithms (MBDCAs) for skin irradiation using surface applicators. Acquisition and Validation Methods The test cases utilize the INTRABEAM 30 mm surface applicator.
Iymad R. Mansour, Christian Valdes‐Cortez, David Santiago Ayala Alvarez, Francisco Berumen, Jean‐Simon Côte, Gaël Ndoutoume‐Paquet, Peter G. F. Watson, Jan Seuntjens, Facundo Ballester, Ernesto Mainegra‐Hing, Rowan M. Thomson, Luc Beaulieu, Javier Vijande   +12 more
wiley   +1 more source

Impact of intracellular radionuclide distribution in a Monte Carlo biophysical 3D multi‐cellular model for targeted alpha therapy

Medical Physics, Volume 52, Issue 7, July 2025.
Abstract Background To understand and predict the therapeutic efficacy of targeted alpha therapy (TAT), nano‐ and microdosimetry are needed to consider the very heterogeneous dose deposition at cellular and subcellular levels. Purpose The objective of this study is to theoretically evaluate the importance of cell internalization of alpha‐emitters on ...
Victor Levrague, Mario Alcocer‐Ávila, Sarah Leilla Otmani, Lydia Maigne, Etienne Testa, Michaël Beuve, Rachel Delorme   +6 more
wiley   +1 more source

Radiopharmaceuticals: From Molecular Imaging to Targeted Radionuclide Therapy

, 2004
P. August Schubiger, Jürgen Grünberg, Simon M. Ametamey, Michael Honer, Elisa García‐Garayoa, Peter Bläuenstein, Robert Waibel, Ilse Novak‐Hofer, Roger Schibli   +8 more
openalex   +2 more sources