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Targeted Radionuclide Therapy - An Overview
Current Radiopharmaceuticals, 2013Radionuclide therapy (RNT) based on the concept of delivering cytotoxic levels of radiation to disease sites is one of the rapidly growing fields of nuclear medicine. Unlike conventional external beam therapy, RNT targets diseases at the cellular level rather than on a gross anatomical level.
Ashutosh, Dash +2 more
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American Journal of Clinical Oncology, 1989
This book presents a survey of uses of parenterally administered radionuclides as therapeutic sources and concentrates on both the basic considerations of each mode of use as well as the clinical results and experiences. This volume provides a source of information for the clinical physician and scientist involved in therapy, and describes current ...
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This book presents a survey of uses of parenterally administered radionuclides as therapeutic sources and concentrates on both the basic considerations of each mode of use as well as the clinical results and experiences. This volume provides a source of information for the clinical physician and scientist involved in therapy, and describes current ...
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The use of radionuclides for tumor therapy
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1986The successful use of radionuclides for tumor therapy depends to a major extent on the ability to achieve a high concentration of radioactivity in the tumor relative to other radiosensitive organs not involved by tumor, such as bone marrow, intestinal mucosa, liver, and kidneys.
R A, Fawwaz +3 more
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Radionuclide therapy of adrenal tumors
Journal of Surgical Oncology, 2012AbstractAdrenal tumors arising from chromaffin cells will often accumulate radiolabeled metaiodobenzylguanidine (MIBG) and thus are amenable to therapy with I‐131 MIBG. More recently, therapy studies have targeted the somatostatin receptors using Lu‐177 or Y‐90 radiolabeled somatostatin analogs.
Jorge A, Carrasquillo +2 more
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Beta-Emitting Radionuclides for Peptide Receptor Radionuclide Therapy
Current Topics in Medicinal Chemistry, 2013The paper focuses on the β-emitting radionuclides which might be useful for peptide receptor radionuclide therapy, PRRT. For the effective design of the radiopharmaceutical, the choice of radionuclide will depend on the purpose for which the radioligand is being used and on the physicochemical properties of the radionuclide.
J L, Parus, R, Mikolajczak
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Radionuclide therapy beyond radioiodine
Wiener Medizinische Wochenschrift, 2012For decades, Iodine-131 has been used for the treatment of patients with thyroid cancer. In recent years, increasingly, other radiopharmaceuticals are in clinical use in the treatment of various malignant diseases. Although in principle these therapies-as in all applications of radionuclides-special radiation protection measures are required, a ...
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Radionuclide therapy of hematologic disorders
Seminars in Nuclear Medicine, 197932P is effective therapy for polycythemia and primary thrombocytosis. The Polycythemia Vera Study Group is comparing radioactive phosphorus with alkylating agents to determine relative efficacy. Less well investigated is the effectiveness of 32P vs. busulfan in chronic granulocytic leukemia. Endolymphatic administration of radiopharmaceuticals may play
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Targeted Radionuclide Therapy in Glioblastoma
ACS Applied Materials & InterfacesDespite the development of various novel therapies, glioblastoma (GBM) remains a devastating disease, with a median survival of less than 15 months. Recently, targeted radionuclide therapy has shown significant progress in treating solid tumors, with the approval of Lutathera for neuroendocrine tumors and Pluvicto for prostate cancer by the US Food and
Xiaobin Zhao +7 more
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Radionuclides and carrier molecules for therapy
Physics in Medicine and Biology, 1996Although radionuclide therapy has been around for a long time, this modality of cancer treatment has been limited mainly to the use of [32P]-phosphate and [131I]-sodium iodide. The last few years, however, have seen an increased interest in this area due to new developments of radionuclides and carrier molecules that may provide selective targeting of ...
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Radiation therapy‐associated toxicity: Etiology, management, and prevention
Ca-A Cancer Journal for Clinicians, 2021Kyle Wang
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