Results 31 to 40 of about 21,291 (235)
Advanced Science, EarlyView.Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu +12 more
wiley +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Advanced Science, EarlyView.This review elucidates URB design strategies, including genetic and physicochemical modifications, while dissecting the synergistic mechanisms governing spatiotemporal control. It further evaluates applications in targeted drug delivery, gene modulation, and immunotherapy, finally offering perspectives on overcoming translational barriers for clinical ...
Xueyao Wang +5 more
wiley +1 more source
Innovative Development of Reactor-Produced Radionuclides and Radiopharmaceuticals
中国工程科学Radionuclides and radiopharmaceuticals produced by reactors are important components and main material foundations of the nuclear healthcare industry. Therefore, summarizing the current status of reactor-produced radionuclides and radiopharmaceuticals is
Peng Shuming +6 more
doaj +1 more source
Biomedical Photonics, 2015 The impact of irregularity in radionuclide coating of scaffold on the distribution of absorbed dose produced by grid of microsources was analyzed.
N. A. Nerosin +3 more
doaj +1 more source
The activity concentrations of 40K, 226Ra, 232Th, 238U and 7Be in moss from spas in eastern Serbia in the period 2000-2012 [PDF]
Archives of Biological Sciences, 2014 In this work we present the activity concentrations of natural radionuclides 40K, 226Ra, 232Th, 238U and 7Be in mosses. One hundred and sixty-seven moss samples were collected between 2001 and 2012 from the territory of the Sokobanja, Banja ...
Čučulović Ana +2 more
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Advanced Science, EarlyView.This work provides an effective strategy for selectively extracting 212Pb and 212Bi from the decay chain of 232Th as well as its mechanism illustration. Using the novel strategy, 2.07 MBq of 212Pb is successfully separated from 232Th and its daughters, which enables the supply of 212Pb/212Bi directly from the abundant natural thorium resource to be ...
Lifeng Chen +11 more
wiley +1 more source
Applied Sciences, 2022 We report a high sensitivity study of actinides content in water and sediment matrices performed for the first time along the Garigliano river, near the nuclear power plant currently undergoing decommissioning, and in the marine environment surrounding ...
Antonio Petraglia +11 more
doaj +1 more source
Ribogospodarsʹka Nauka UkraïniPurpose. To determine the radiation state of the ecosystem in the technologically modified Konoplyanka River in the area of radioactive waste tailings dump and the mouth of the river (at the siteof confluence with the Zaporizhzhya (Dnipro) Reservoir ...
N. Hudym
doaj +1 more source