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2019
Copper (Cu) is a transition metal with atomic number 29, involved in several physiological processes, being cofactor for numerous enzymes, such as the “Cu/Zn superoxide dismutase,” “cytochrome-C-oxidase,” “tyrosinase,” “ceruloplasmin,” and other proteins.
Antonio Bagnato +6 more
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Copper (Cu) is a transition metal with atomic number 29, involved in several physiological processes, being cofactor for numerous enzymes, such as the “Cu/Zn superoxide dismutase,” “cytochrome-C-oxidase,” “tyrosinase,” “ceruloplasmin,” and other proteins.
Antonio Bagnato +6 more
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Fatty acid-conjugated radiopharmaceuticals for fibroblast activation protein-targeted radiotherapy
European Journal of Nuclear Medicine and Molecular Imaging, 2021Pu Zhang +6 more
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Anti-cancer radiopharmaceuticals
Anti-Cancer Drugs, 1991Therapeutic nuclear medicine is rapidly developing as an additional treatment modality in oncology. A great variety of specific tumor-seeking radiopharmaceuticals is applied both for diagnostic scintigraphy and treatment, using multiple routes and mechanisms to target radionuclides at tumors.
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Characteristics of Specific Radiopharmaceuticals
1979In Chapter 6 the general principles of labeling methods were discussed, particularly iodination and 99mTc-labeling, and kit preparation of 99mTc-radiopharmaceuticals was described. In this chapter the basic principles of preparation, labeling yield, stability, storage conditions, and other characteristics of several radiolabeled compounds most commonly
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Radiopharmaceuticals for Therapy
2019Therapeutic radiopharmaceuticals exert their radiobiological action through the emission of electrically charged particles (α++ particles, β− particles, Auger electrons) that deposit their energy within a limited range in tissue—from fraction of a micrometer to a few millimeters at most.
Federica Guidoccio +2 more
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Novel Radiopharmaceuticals for Therapy
2016In the era of personalizedmedicine, "target radionuclide therapy" (TRT) is designed to damage only the cancerous cells while sparing unnecessary damage to the adjacent healthy cells/tissues. Unlike conventional external beam radiation therapy, TRT is intended to cause less or no collateral damage to normal tissues, as it aims at achieving targeted drug
Guidoccio F. +4 more
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Radiopharmaceuticals and Methods of Radiolabeling [PDF]
, 1992 A radiopharmaceutical is a radioactive compound used for the diagnosis and therapeutic treatment of human diseases. In nuclear medicine nearly 95% of the radiopharmaceuticals are used for diagnostic purposes, while the rest are used for therapeutic treatment. Radiopharmaceuticals usually have minimal pharmacologic effect, because in most cases they are
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Microreactors for radiopharmaceutical synthesis
Lab on a Chip, 2009Multiple advantages of microfluidics have been demonstrated in the area of organic synthesis. However, only a limited number of them have found applications in radiopharmaceutical synthesis, while that is an area where the need for improvements offered by microfluidics is very significant.
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