Results 61 to 70 of about 2,807 (168)

The Application of PD‐1 Inhibitors in Immunotherapy for Glioblastoma

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
The molecular mechanism of PD‐1. When PD‐1 binds to PD‐L1, the ITIM and ITSM domains within PD‐1 are phosphorylated and subsequently recruit SHP‐2. This then dephosphorylates downstream molecules of the TCR, such as PI3K/AKT and ZAP70, reduces the secretion of IFN‐γ, and inhibits the presentation of antigens to T cells via MHC molecules through the ...
Ming‐zhen Dong, Ming Cui, Lin‐zhuo Qu, Hui‐ying Che, Hong‐jian Guan   +4 more
wiley   +1 more source

Ethnic and Gender Disparities in Access to Deep Brain Stimulation Surgery for Parkinson's Disease

Movement Disorders Clinical Practice, Volume 13, Issue 2, Page 430-441, February 2026.
Abstract Background Deep brain stimulation (DBS) is an established treatment for Parkinson's disease (PD) in appropriately selected patients. DBS may be underused in certain patient populations, especially women and racialized groups. Barriers and biases to receiving DBS that could account for underuse among these groups are not well studied in Canada.
Fang Ba, Sabrina Poonja, Pouria Torabi, Kevin Yen, Bashir Daud Shah, Eric Noyes, Gail Dimapilis, Shaina Corrick, Tejas Sankar, Alex Rajput, Oury Monchi, Aleksander M. Vitali, Bukola Salami, Aakash Shetty, Janis M. Miyasaki   +14 more
wiley   +1 more source

Knowledge‐based deep residual U‐Net (DRU) for synthetic CT generation using a single MR volume for frameless radiosurgery

Journal of Applied Clinical Medical Physics, Volume 27, Issue 1, January 2026.
Abstract Purpose To develop a knowledge‐based deep model for sCT generation from a single MR volume in LINAC‐based frameless SRS, enabling the MR‐only workflow without extra CT simulation. Methods A total of 139 patients were included in the study, with 120 used for training and 19 for testing.
Xiwen Shu, Ke Lu, Jingtong Zhao, John Ginn, Yongbok Kim, Zhenyu Yang, Justus Adamson, Trey Mullikin, Chunhao Wang   +8 more
wiley   +1 more source

RapidArc dynamic versus RapidArc: A multi anatomical‐site dosimetric evaluation

Journal of Applied Clinical Medical Physics, Volume 27, Issue 1, January 2026.
Abstract Background RapidArc (RA) has advanced VMAT delivery; however, challenges remain in achieving optimal organ‐at‐risk (OAR) sparing in complex cases. RapidArc Dynamic (RAD), a next‐generation Volumetric Modulation Arc Therapy (VMAT) technique, incorporates dynamic collimator rotation, embedded static fields, and a faster optimizer to enhance dose
Aram Rostami, Carole Naim, Renilmon Pottanplackal Sukumaran, Mohammad Usman, Abbass Yousef Mkanna, Alla Fuad Al‐Sabahi, Ahamed Basith, Shelton Chuck, Mojtaba Barzegar, Bevan Orville Peltier, Bassim Aklan, Samaneh Baradaran, Satheesh Prasad Paloor, Rabih Wafiq Hammoud   +13 more
wiley   +1 more source

Assessing local control, toxicity with hippocampal avoidance whole-brain radiotherapy with a simultaneous integrated boost for single and limited brain metastases

Asian Journal of Medical Sciences
Background: Although whole-brain radiotherapy (WBRT) has been the standard treatment for brain metastases, its cognitive side effects have led to the rise of stereotactic radiosurgery (SRS), which offers better local control with less neurocognitive ...
Poopalan Sivakumar , Dhanushkodi Paramasivam , Prabhuraj Muthu , Deivanayagam Ramasundaram , Sindhuja Vijayan   +4 more
doaj   +1 more source

Sinonasal Sarcomas Management: An International Consensus Statement

International Forum of Allergy &Rhinology, Volume 16, Issue 1, Page 55-69, January 2026.
ABSTRACT Introduction Sinonasal sarcomas are exceedingly rare entities, constituting less than 7% of head and neck sarcomas. Their complex histology needs specialized treatment, which is often based on multimodal approaches including surgery, radiation therapy, and/or chemotherapy.
Alessandro Vinciguerra, Francesca Caspani, Marco Valentini, Anna Maria Camarda, Salvatore Provenzano, Eric W. Wang, Cem Meço, Marco Ferrari, Pavol Surda, Semi Harrabi, Fernando Augusto Batista Campos, Javier Martin Broto, B. Ashleigh Guadagnolo, Pierina Navarria, Ali Hosni, Nadia Hindi, Antoine Italiano, Daniel M. Trifiletti, Bernd Kasper, Benjamin Verillaud, Alberto Schreiber, Paolo Castelnuovo, Piero Nicolai, Iacopo Dallan, Matias Chacon, Shirley Y. Su, Juliette Thariat, Claudia Valverde, Matt Lechner, Jean Yves Blay, Maria Rosaria Fiore, Jean Anderson Eloy, Mehdi Brahmi, James N. Palmer, Victor Castro Oliden, Daniela Greto, Iwona Lugowska, Angelo Paolo Dei Tos, Thibaut van Zele, Alkis J. Psaltis, Paolo Giovanni Casali, Armelle Dufresne, Claudia Sangalli, Christos Georgalas, Ester Orlandi, Peter‐John Wormald, Philippe Herman, Ricardo Carrau, Ehab Y. Hanna, Lisa Licitra, Mario Turri‐Zanoni, Paolo Battaglia   +51 more
wiley   +1 more source

A Systematic Review of the Parkinson's Foundation Hospital Care Recommendations

Movement Disorders Clinical Practice, Volume 13, Issue 1, Page 29-43, January 2026.
Abstract Background People with Parkinson's disease (PwP) face increased risks of complications and longer hospital stays compared to the general population. Four major factors contribute to increased morbidity and mortality during hospitalization: medication timing errors, administration of harmful medications, restricted mobility, and dysphagia ...
Ariane Veilleux Carpentier, Irene A. Malaty, Peter A. LeWitt, Hooman Azmi, Anne Brooks, Edward Pollak, Ellen L. Air, Heather Simpson, Jaime Thomas, Florian P. Thomas, Lisa Cocoziello, Sheera Rosenfeld, Michael S. Okun   +12 more
wiley   +1 more source

Long-term outcomes with reduced-dose whole-brain radiotherapy and a stereotactic radiosurgery boost for primary central nervous system lymphoma. [PDF]

Neurooncol Adv, 2023
Foreman BE, Mullikin TC, Floyd SR, Kelsey CR, Patel MP, Peters KB, Kirkpatrick JP, Reitman ZJ, Vaios EJ.   +8 more
europepmc   +1 more source

Intensity-modulated radiotherapy with planned Gamma Knife radiosurgery boost for head and neck cancer with extensive disease in proximity to critical structures. [PDF]

Head Neck, 2022
Farris JC, Steber CR, Black PJ, Chan MD, Ververs JD, Cramer CK, Browne JD, Waltonen JD, Sullivan CA, Patwa HS, Laxton AW, Tatter SB, Frizzell BA, Porosnicu M, Lycan TW, Greven KM, Hughes RT.   +16 more
europepmc   +1 more source

Stereotactic ablative radiotherapy for treating primary head and neck cancer and locoregional recurrence: A comprehensive review of the literature

Clinical and Translational Radiation Oncology
Introduction: Although stereotactic ablative radiotherapy (SABR) has advance to standard-of-care for many different indications like lung and liver malignancies, it still remains in its infancy for treating head and neck cancer.
Ciro Franzese, Panagiotis Balermpas
doaj   +1 more source