Results 151 to 160 of about 829,320 (360)

Epirubicin With Cyclophosphamide Followed by Docetaxel With Trastuzumab and Bevacizumab as Neoadjuvant Therapy for HER2-Positive Locally Advanced Breast Cancer or as Adjuvant Therapy for HER2-Positive Pathologic Stage III Breast Cancer: A Phase II Trial of the NSABP Foundation Research Group, FB-5 [PDF]

, 2017
Background The purpose of this study was to determine the cardiac safety and clinical activity of trastuzumab and bevacizumab with docetaxel after epirubicin with cyclophosphamide (EC) in patients with HER2-positive locally advanced breast cancer (LABC ...
Ansari, Bilal, Buyse, Marc E., Conlin, Alison K., Geyer, Charles E., Jr., Gross, Howard M., Jacobs, Samuel A., Keogh, George P., Lord, Raymond S., Mamounas, Eleftherios P., Mauquoi, Celine, Patocskai, Erica J., Polikoff, Jonathan A., Rastogi, Priya, Robidoux, André, Smith, John W., Stella, Philip J., Swain, Sandra M., Wolmark, Norman   +17 more
core   +2 more sources

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

Advanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang, Lin Tang, Yusi Wang, Xuejing Zhou, Zhenyu Ding, Li Yang   +5 more
wiley   +1 more source

Effectiveness of Adjuvant Chemo- and Radiotherapy in Thymic Carcinoma Stage II: A Systematic Review and Meta-Analysis

Cancer Control
Background Thymic carcinoma is a rare tumor arising from the epithelial thymic tissue, yet among mediastinal tumors, it is the most common malignant entity. Thymic carcinoma often causes no symptoms and is incidentally discovered.
Ahmad Nazzal MD, Josef Yayan MD, PhD, Christian Biancosino MD, PD, Seyed Vahid Tabatabaei MD, Khosro Hekmat MD   +4 more
doaj   +1 more source

What information could the main actors of liquid biopsy provide? A representative case of non-small cell lung cancer (NSCLC) [PDF]

, 2018
In non-small cell lung cancer (NSCLC), there is a consensus regarding the use of liquid biopsy, generally, to detect "druggable" mutations and, in particular, to monitor tyrosine kinase inhibitor (TKI) treatments. However, whether circulating tumor cells
Manicone, M., Mariotta, S., Pezzuto, A., Ricci, A., Rossi, Elisabetta, Scaini, M. C., Zamarchi, R.   +6 more
core   +1 more source

PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti‐TIGIT Therapy in Microsatellite‐Stable Colorectal Cancer

Advanced Science, EarlyView.
Microsatellite‐stable (MSS) colorectal cancer (CRC) resists immunotherapy. PRMT5 inhibition enhances CPT‐11 sensitivity, inducing a PMS2‐deficient‐like state and cytosolic dsDNA release, which activates the cGAS‐STING pathway to promote anti‐tumor immunity. However, this combination therapy upregulates TIGIT expression on CD8+ T cells, and the addition
Jiang Zhu, Shenao Fu, Xi Zou, Hanjiang Zeng, Guangzu Cui, Yinghui Peng, Diya Tang, Fan Zhang, Hong Shen, Shan Zeng, Ying Han   +10 more
wiley   +1 more source

Towards a Multiphysics Model for Tumor Response to Combined-Hyperthermia-Radiotherapy Treatment [PDF]

arXiv, 2019
We develop a multiphysics-based model to predict the response of localized tumors to combined-hyperthermia-radiotherapy (CHR) treatment. This procedure combines hyperthermia (tumor heating) with standard radiotherapy to improve efficacy of the overall treatment. In addition to directly killing tumor cells, tumor heating amends several parameters within
arxiv  

Pediatric extraspinal sacrococcygeal ependymoma (ESE): an Italian AIEOP experience of six cases and literature review [PDF]

, 2018
Background: Primary pediatric extraspinal sacrococcygeal ependymoma (ESE) is a very rare disease, poorly described in literature, whose diagnostic, therapeutic, and follow-up approach is still controversial.
Antonelli, Manila, Biassoni, Veronica, Cesaro, Simone, Gandola, Lorenza, Modena, Piergiorgio, Pierani, Paolo, Schiavello, Elisabetta   +6 more
core   +1 more source

Single‐Cell Analysis Reveals that Vitamin C Inhibits Bone Metastasis of Renal Cancer via Cell Cycle Arrest and Microenvironment Remodeling

Advanced Science, EarlyView.
3D‐cultured renal cancer cells exhibit stem‐like phenotypes and are more efficient in generating bone metastases. Vitamin C treatment can suppress the development of bone metastasis. Single‐cell transcriptomic analysis reveals that vitamin C inhibits metastasis by inducing tumor cell cycle arrest, suppressing osteoclast differentiation, and reducing ...
Jianye Zhang, Qi Zhang, Gang Lin, Ying Wang, Juan Li, Ping Wang, Jie Qi, Yuan Liang, Shiming He, Yanqing Gong, Ninghan Feng, Yang Wang, Yuanyuan Ma, Mei Zhang, Yue Shi, Xuesong Li, Weimin Ci, Liqun Zhou   +17 more
wiley   +1 more source

Reliability of Reconstructed Breast Flap after Chemotherapy and Radiotherapy in Immediate Breast Reconstruction [PDF]

Archives of Plastic Surgery, 2012
BackgroundPostmastectomy adjuvant therapy is used to prevent locoregional recurrence and improve overall breast cancer specific survival rates. However, it can adversely affect the cosmetic results of reconstruction.
Keun-Cheol Lee, Tae-Heon Kim, Su-Seong Park, Min-Su Kim, Myung-Hoon Kim, Seok-Kwun Kim, Se-Heon Cho, Mi-Ri Lee, Jin-Hwa Lee, Hyung-Sik Lee, Dae-Cheol Kim   +10 more
doaj  

Photon-Counting CT in Cancer Radiotherapy: Technological Advances and Clinical Benefits [PDF]

Photon-counting computed tomography (PCCT) marks a significant advancement over conventional energy-integrating detector (EID) CT systems. This review highlights PCCT's superior spatial and contrast resolution, reduced radiation dose, and multi-energy imaging capabilities, which address key challenges in radiotherapy, such as accurate tumor delineation,
arxiv   +1 more source