Results 91 to 100 of about 35,736 (252)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Multicentre prospective risk analysis of a fully automated radiotherapy workflow

Physics and Imaging in Radiation Oncology
Background and Purpose: Fully automated workflows (FAWs) for radiotherapy treatment preparation are feasible, but remain underutilized in clinical settings.
Geert De Kerf, Ana Barragán-Montero, Charlotte L. Brouwer, Pietro Pisciotta, Marie-Claude Biston, Marco Fusella, Geoffroy Herbin, Esther Kneepkens, Livia Marrazzo, Joshua Mason, Camila Panduro Nielsen, Koen Snijders, Stephanie Tanadini-Lang, Aude Vaandering, Tomas M. Janssen   +14 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Evaluating the Effectiveness of Proton Beam Therapy Compared to Conventional Radiotherapy in Non-Metastatic Rectal Cancer: A Systematic Review of Clinical Outcomes

Medicina
Background and Objectives: Conventional radiotherapies used in the current management of rectal cancer commonly cause iatrogenic radiotoxicity. Proton beam therapy has emerged as an alternative to conventional radiotherapy with the aim of improving ...
Kelvin Le, James Norton Marchant, Khang Duy Ricky Le   +2 more
doaj   +1 more source

Optimization of Heart Block in the Left-sided Whole Breast Radiation Treatments

Frontiers in Oncology, 2014
Purpose: Blocks have been used to protect heart from potential radiation damage in left-sided breast treatments. Since cardiac motion pattern may not be fully captured on conventional 3DCT or 4DCT simulation scans, this study was intended to investigate ...
Ning Jeff Yue, Sharad eGoyal, Joohan ePark, Sheri eJones, Xiaoting eXu, Atif eKhan, Bruce George Haffty, Ting eChen   +7 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Organ at Risk Segmentation in Head and Neck CT Images Using a Two-Stage Segmentation Framework Based on 3D U-Net

IEEE Access, 2019
Accurate segmentation of organs at risk (OARs) plays a critical role in the treatment planning of image-guided radiotherapy of head and neck cancer. This segmentation task is challenging for both humans and automated algorithms because of the relatively ...
Yueyue Wang, Liang Zhao, Manning Wang, Zhijian Song   +3 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Fully automatic liver segmentation combining multi-dimensional graph cut with shape information in 3D CT images

Scientific Reports, 2018
Liver segmentation is an essential procedure in computer-assisted surgery, radiotherapy, and volume measurement. It is still a challenging task to extract liver tissue from 3D CT images owing to nearby organs with similar intensities.
Xuesong Lu, Qinlan Xie, Yunfei Zha, Defeng Wang   +3 more
doaj   +1 more source

Computer- and robot-assisted Medical Intervention

, 2009
Medical robotics includes assistive devices used by the physician in order to make his/her diagnostic or therapeutic practices easier and more efficient. This chapter focuses on such systems.
Troccaz, Jocelyne
core   +1 more source