Results 121 to 130 of about 962,920 (362)

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Impact of magnetic resonance-guided versus conventional radiotherapy workflows on organ at risk doses in stereotactic body radiotherapy for lymph node oligometastases

Physics and Imaging in Radiation Oncology, 2022
Background and purpose: Magnetic resonance (MR)-linac delivery is expected to improve organ at risk (OAR) sparing. In this study, OAR doses were compared for online adaptive MR-linac treatments and conventional cone beam computed tomography (CBCT)-linac ...
Anita M. Werensteijn-Honingh, Petra S. Kroon, Dennis Winkel, J. Carlijn van Gaal, Jochem Hes, Louk M.W. Snoeren, Jaleesa K. Timmer, Christiaan C.P. Mout, Gijsbert H. Bol, Alexis N. Kotte, Wietse S.C. Eppinga, Martijn Intven, Bas W. Raaymakers, Ina M. Jürgenliemk-Schulz   +13 more
doaj  

A network approach to quantifying radiotherapy effect on cancer: Radiosensitive gene group centrality [PDF]

arXiv, 2018
Radiotherapy plays a vital role in cancer treatment, for which accurate prognosis is important for guiding sequential treatment and improving the curative effect for patients. An issue of great significance in radiotherapy is to assess tumor radiosensitivity for devising the optimal treatment strategy.
arxiv  

Short Textbook of Radiotherapy for Technicians and Students [PDF]

, 1951
J. Walter, H. Miller
openalex   +2 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

MALIGNANCIES OF THE THYMUS [PDF]

: The role of radiotherapy in the treatment of thymoma and thymic carcinoma has been evaluated by many investigators over the past two decades. The low incidence of these neoplasms has limited most published studies to small series spanning long time ...
Charles R. Thomas, Radiotherapy For Thymic Neoplasms   +1 more
core  

Prediction of the treatment effect of FLASH radiotherapy with Circular Electron-Positron Collider (CEPC) synchrotron radiation [PDF]

arXiv
The Circular Electron-Positron Collider (CEPC) can also work as a powerful and excellent synchrotron light source, which can generate high-quality synchrotron radiation. This synchrotron radiation has potential advantages in the medical field, with a broad spectrum, with energies ranging from visible light to x-rays used in conventional radiotherapy ...
arxiv  

Repopulation: is it inevitably? [PDF]

arXiv, 2006
A mathematical model of radiotherapy is proposed. The study used the classical 24 hours way of fractionation with a weekend pause. We introduce the matrices of ``radiotherapy'' and ``growth''. We developed an equation of the fraction cell evolution, which we solved numerically. The results indicate that the accelerated growth of cells occurs due to the
arxiv  

The Scope of Radiotherapy in Carcinoma of the Bronchus [PDF]

, 1953
Gwen Hilton
openalex   +1 more source