Results 191 to 200 of about 510,570 (268)

Heart Substructure Radiation Dose and Cardiac Outcomes: Contemporary Evidence and Actionable Opportunities: JACC CardioOncology State-of-the-Art Review. [PDF]

JACC CardioOncol
Atkins KM, Walls G, Nikolova AP, Ferrall J, Oorloff M, Bychowski J, Kolb K, Karlstaedt A, Mitchell JD, Mak RH, Bergom C.   +10 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Observed Versus Expected Use of Diagnostic Imaging and Radiotherapy in Prostate Cancer in the Lazio Region (Italy): An Integrated Population-Based and Literature-Informed Framework for Healthcare Planning. [PDF]

Healthcare (Basel)
Ferranti M, Nardi A, Zijno M, Carloni E, Lopes S, Cozzi I, Santelli E, Farchi S, D'Ippoliti D, Michelozzi P, Pinnarelli L.   +10 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Targeting Ferroptosis to Overcome Radioresistance and Enhance Immunotherapy in Colorectal Cancer. [PDF]

Cells
Soltani Tehrani S, Olson SI, Kundu K, Ferrandon S, Kalady MF.   +4 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

First-line serplulimab plus chemotherapy versus chemotherapy alone in small-cell lung cancer patients with brain metastases: a multicenter, prospective cohort study. [PDF]

Front Immunol
Zhang W, Yang X, Chen H, Pu X, Tuohetashi R, Wu X, Xie Z, Wu D, Cai Y, Jin S, Guo X, Yao K, Chen Y, Jiang G.   +13 more
europepmc   +1 more source

Mapping the radiotherapy journey of patients with head and neck cancer: A qualitative study. [PDF]

Asia Pac J Oncol Nurs
Yang S, Wang S, Han M, Wang J, Chen L.
europepmc   +1 more source

Radiobiotherapy in Osteosarcoma: A State-Based Educational Framework for Strategy Selection and Trial Design. [PDF]

Curr Oncol
Vijayakumar S, Lewis S, Matrana M, Vasquez RJ, Singh A, Duesbery N, Collier AB, Larned Z, Barr J, Orr WR, Nittala MR, Vijayakumar V.   +11 more
europepmc   +1 more source

Robustness of tumor control (TCP) and normal tissue complication probabilities (NTCP) for intensity modulated particle radiotherapy in locally advanced lung cancer: a scenario-based uncertainty analysis compared to photon radiotherapy (IMRT). [PDF]

J Thorac Dis
Ming X, Sheng Y, Chen J, Wu K, Wang X, Mao J, Ma N.   +6 more
europepmc   +1 more source