Results 191 to 200 of about 1,093,427 (365)

Advanced radiotherapy and systemic therapy in head and neck adenoid cystic carcinoma: Current progress and future integrated strategies. [PDF]

Transl Oncol
Liu L, Zhou X, Li L, Yang J, Tan M.
europepmc   +1 more source

The quality of survival of patients with malignant cerebal glioma following radiotherapy

, 1998
PhDObjective- To describe survival, disability and morbidity after radiotherapy for malignant glioma and explore patient and relative experience. Design - Home follow-up of patients and relative over up to 24 months and of relatives after bereavement.
Davies, Elizabeth
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

From Cellular Radiosensitivity to Precision Radiotherapy: Integrating Functional Assays, Genomics, and Clinical Modeling. [PDF]

Cancers (Basel)
Gkikoudi A, Triantopoulou S, Markellou E, Xynou V, Vasilopoulos SN, Myronakis M, Laiakis EC, Theodorou K, Terzoudi GI, Georgakilas AG.   +9 more
europepmc   +1 more source

Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma.

New England Journal of Medicine, 2014
O. Chinot, W. Wick, W. Mason, R. Henriksson, F. Saran, R. Nishikawa, A. Carpentier, K. Hoang-Xuan, P. Kavan, D. Cernea, A. Brandes, M. Hilton, L. Abrey, T. Cloughesy   +13 more
semanticscholar   +1 more source

Artificial intelligence-assisted radiotherapy for pelvic and abdominal malignancies: assessing feasibility in the context of Africa-specific risks. [PDF]

Front Oncol
Fiagbedzi E, Acquah GF, Baidoo AM, Osei-Poku L, Pokoo-Aikins M, Dery T, Agyabeng A, Issahaku S, Sackey TA, Adu-Poku M, Sosu EK, Tagoe S, Addison ECK, Hasford F, Stoeva M.   +14 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Nutritional risk and cancer pain as determinants of radiotherapy-induced severe lymphocytopenia: development and validation of a nutrition-integrated predictive nomogram. [PDF]

Front Nutr
Gao M, Dong T, Yuan M, Zhang H, Zhang X, Chen Q, Liu C.   +6 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Implications of a New Generation of Tissue Expanders for Post-Mastectomy Radiotherapy in Breast Reconstruction: A Retrospective Single-Center Study. [PDF]

J Clin Med
Caputo GG, Scarabosio A, Pisano G, Giunco C, Prisco A, Moretti E.   +5 more
europepmc   +1 more source