Results 41 to 50 of about 445,958 (265)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Practical Method to Evaluate the Stiffness of Fractured Radius

Methods and Protocols, 2023
Distal radius fractures (DRFs) are one of the most common fractures of the upper extremity system. To evaluate the performance of DRF treatments, the construct (i.e., a DRF fixed by an implant) was compressed at the distal radius in the axial direction ...
Nitikorn Noraphaiphipaksa, Surangkana Katepun, Thanapong Waitayawinyu, Chaosuan Kanchanomai   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Is dorsal cortex drilling necessary for distal radius fractures treated with a volar locking plate? A comparative study of near-cortex-only and far-cortex drilling [PDF]

Journal of Trauma and Injury
Purpose This study aimed to compare and analyze the effectiveness of near-cortex-only drilling for the surgical treatment of distal radius fractures using a volar locking plate.
Chul Hong Kim, Sung Yoon Jung, Hyeon Jun Kim, Si-Hyun Park   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Geometry repeatability and prediction for personalized medical devices made using multi-jet fusion additive manufacturing

Additive Manufacturing Letters
As additive manufacturing (AM) production volumes grow to the industrial scale, quality systems must also scale to verify that every part satisfies requirements.
Christopher H. Conway, Davis J. McGregor, Tristan Antonsen, Charles Wood, Chenhui Shao, William P. King   +5 more
doaj   +1 more source

Dadagulella radius var. radius radius (Preston 1910, comb. nov.

, 2013
Dadagulella radius radius (Preston, 1910) comb. nov. Figs 1-5, 9-20, 43-45, 52-53, 65, 69, 73, 77-78, 83-84; Table 1 Ennea radius Preston, 1910: 529, pl. VII, fig. 8. Gulella radius – Verdcourt 1962: 13, 17,? not 22 (see D. radius calva below). — van Bruggen 1969: 71. — Verdcourt 1983: 234; 1985: 119, fig. 17; 1996: 136. — Tattersfield 1998a: 83; 1998b:
Rowson, Ben, Tattersfield, Peter
openaire   +2 more sources

Cliques and the spectral radius

Journal of Combinatorial Theory, Series B, 2007
We present a number of relations involving the number of cliques in a graph and its spectral radius.
Béla Bollobás, Vladimir Nikiforov 0001
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source