Results 131 to 140 of about 36,710 (271)

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Extending the hyper‐logistic model to the random setting: New theoretical results with real‐world applications

Mathematical Methods in the Applied Sciences, EarlyView.
We develop a full randomization of the classical hyper‐logistic growth model by obtaining closed‐form expressions for relevant quantities of interest, such as the first probability density function of its solution, the time until a given fixed population is reached, and the population at the inflection point.
Juan Carlos Cortés, Ana Navarro‐Quiles, Sorina Madalina Sferle   +2 more
wiley   +1 more source

An inversion of the conical Radon transform arising in the Compton camera with helical movement. [PDF]

Biomed Eng Lett, 2019
Kwon K.
europepmc   +1 more source

Existence of Solution for Two Classes of Quasilinear Systems Defined on a Nonreflexive Orlicz–Sobolev Spaces

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT This paper proves the existence of nontrivial solution for two classes of quasilinear systems of the type −ΔΦ1u=Fu(x,u,v)+λRu(x,u,v)inΩ−ΔΦ2v=−Fv(x,u,v)−λRv(x,u,v)inΩu=v=0on∂Ω$$ \left\{\begin{array}{l}\hfill -{\Delta}_{\Phi_1}u={F}_u\left(x,u,v\right)+\lambda {R}_u\left(x,u,v\right)\kern0.1832424242424242em \mathrm{in}\kern0.3em \Omega ...
Lucas da Silva, Marco Souto
wiley   +1 more source

An Improved Air Film Model for Studying the Tilt Characteristics of Aerostatic Thrust Bearings

International Journal of Mechanical System Dynamics, EarlyView.
ABSTRACT In this study, an improved mass‐spring model that treats the lubricating air film as distributed springs is proposed to calculate the static and dynamic angular stiffness of aerostatic thrust bearings. The proposed model refines the traditional mass‐spring model by introducing the spatially varying mechanical properties of the air film and the
Hui Zhuang, Jianguo Ding, Yu Chang
wiley   +1 more source

From the brink of extinction to regulation: northern Europe's white‐tailed eagles now face density dependence and climate constraints after rapid population growth

Oikos, EarlyView.
Population growth reflects the combined influence of regulation and density‐independent factors operating through demographic processes. Under exceptional circumstances (e.g. populations recovering from near‐extinction), growth may initially be weakly regulated but typically slows as negative density dependence (NDD) sets in.
Bård‐Jørgen Bårdsen, Elisabeth Hansen, Jan Ove Bustnes   +2 more
wiley   +1 more source

Segmentation-free Radon transform algorithm to detect orientation and size of tissue structures in multiphoton microscopy images. [PDF]

J Biomed Opt
Brandt D, Nikishina AA, Bias A, Günther R, Hauser AE, Duda GN, Beckers IE, Niesner RA.   +7 more
europepmc   +1 more source

Green's function for anisotropic dispersive poroelastic media based on the Radon transform and eigenvector diagonalization. [PDF]

Proc Math Phys Eng Sci, 2019
Zhan Q, Zhuang M, Fang Y, Liu JG, Liu QH.   +4 more
europepmc   +1 more source

Calibrating p‐values in ecology: a practical framework for integrating prior plausibility into statistical inference

Oikos, EarlyView.
Misinterpretation of p‐values, coupled with insufficient consideration of the prior plausibility of ecological hypotheses, leads to overconfident and often unreliable inference in ecological research. To address this issue, we present a methodological framework for p‐value calibration that reinterprets conventional p‐values through minimum Bayes ...
Rafael Dettogni Guariento, Anderson da Rocha Gripp, Adriano Caliman   +2 more
wiley   +1 more source