Results 41 to 50 of about 51,172 (208)

Modulating the Swelling Behavior of Polymer Brushes via Interfacial Chemistry

Angewandte Chemie, EarlyView.
Modulating substrate surface chemistry of surface‐grafted polymer brushes via variation of the chemical composition of spacers that anchor initiators for surface‐initiated atom transfer polymerizations allows to tune swelling of these thin polymer films.
Kuljeet Kaur, Sabrina Sant, Leon A. Smook, Sissi de Beer, Harm‐Anton Klok   +4 more
wiley   +2 more sources

Cancer‐Associated Fibroblast‐Derived Sphingosine‐1‐Phosphate Activates a MALL–SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer

Advanced Science, EarlyView.
CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng, Mengdie Cao, Hai Huang, Shuya Bai, Luyao Liu, Jingwen Liang, Haochen Cui, Qiaodan Zhou, Shiru Chen, Jiamei Jiang, Luoxia Liu, Zhou Luan, Wei Chen, Si Xiong, Ronghua Wang, Bin Cheng, Yuchong Zhao   +16 more
wiley   +1 more source

Tailored Nanogel Network Topology Enables Clinical Ultrasound‐Induced Mechanochemical Activation for In Vivo Therapy

Angewandte Chemie, EarlyView.
The strategy of engineering nanogel network topology is developed to achieve iterative activation of mechanophores upon high‐frequency and low‐intensity ultrasound. This places the nanogel system among the systems that can respond to the ultrasound with the highest frequency and lowest intensity as well as have the fastest activation rate so far.
Helin Li, Fangyin Song, Xiaoye Hu, Li Jing, Qi Shuai, Weike Su, Andrij Pich, Xin Li   +7 more
wiley   +2 more sources

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Oxygen‐Tolerant Photo‐Induced Miniaturized Accelerated Atom Transfer Radical Polymerization (OPTIMA‐ATRP) for High‐Throughput Synthesis of Polymer Bioconjugates

Angewandte Chemie, EarlyView.
Oxygen‐tolerant photo‐induced miniaturized accelerated atom transfer radical polymerization (OPTIMA‐ATRP) in water was developed for the polymerization of hydrophilic (meth)acrylate monomers under ambient or sub‐ambient (4°C) temperature and atmospheric conditions, without prior degassing, in less than 10 min, at an ultra‐small scale (< 50 µL) in ...
Arman Moini Jazani, Roksana Wygoda, Hironobu Murata, Mozhdeh Madadi, Grzegorz Przesławski, Krzysztof Matyjaszewski   +5 more
wiley   +2 more sources

Oligopeptides/DNA Coacervate Droplets as Macromolecular Delivery Microcarriers

Advanced Science, EarlyView.
Oligopeptide–DNA coacervates formed via liquid–liquid phase separation serve as programmable carriers for macromolecular cargos, entering cells through lipid raft–associated pathways and subsequently undergoing enzyme triggered intracellular disassembly driven by DNA degradation processes, thereby enabling efficient, controlled, and spatially defined ...
Linyi Zhang, Chong Wang, Mengqi Han, Yi Yang, Teng Ma, Luoran Shang   +5 more
wiley   +1 more source

3D‐Printable Nanoporous Thermosets via Disulfide‐Based Polymerization‐Induced Microphase Separation

Angewandte Chemie, EarlyView.
α‐Lipoic acid‐derived degradable macro‐chain transfer agents (macroCTAs) with tunable hydrophilicity drive polymerization‐induced microphase separation (PIMS) in photocurable resins. Selective etching via disulfide cleavage then generates interconnected nanoporous thermosets, and compatibility with liquid‐crystal display (LCD) 3D printing enables the ...
Xueheng Dai, Kenny Lee, Yuan Xiu, Nathaniel Corrigan, Kun Zhou, Xichuan Li, Christopher M. Bates, Craig J. Hawker, Cyrille Boyer   +8 more
wiley   +2 more sources

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Localized Accumulation of Tri‐n‐Propylamine Prolongs Electrochemiluminescence for Tumor Model Spheroid Analysis

Angewandte Chemie, EarlyView.
Here, we enhance the electrochemiluminescence imaging of cellular spheroids using [Ru(bpy)3]2+/TPrA chemistry. Our strategy, which involves pre‐incubation with TPrA, enables high‐resolution, long‐term visualization of cellular spheroids without phototoxicity.
Vanshika Gupta, Megan L. Hill, Samuel P. Nortz, Yashvi Choudhary, Ashutosh Rana, Jeffrey E. Dick   +5 more
wiley   +2 more sources

High‐Speed Altitude Regulation With Neuromorphic Camera and Lightweight Embedded Computation

Advanced Intelligent Systems, EarlyView.
Neuromorphic cameras deliver rapid, high‐dynamic‐range sensing but overwhelm embedded processors at high speeds. This work presents a lightweight, optimized Lucas–Kanade optical flow method with parallelization, gyroscopic derotation, and adaptive event slicing.
Simon L. Jeger, Alessandro Marchei, Charbel Toumieh, Dario Floreano   +3 more
wiley   +1 more source