Results 91 to 100 of about 2,584,400 (274)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The ethics of knowledge sharing: a feminist examination of intellectual property rights and open-source materials in gender transformative methodologies

Frontiers in Research Metrics and Analytics
Debates on intellectual property rights and open source frequently stem from the business sector and higher education, where goals are typically oriented toward profit, academic status, credit, and/or reputation.
Leah Goldmann, Alice Welbourn, Diane Gillespie, Nastnet Ghebrebhran, Lufuno Barro, Sara Siebert, Hawa Kagoya, Lori Michau, Anjalee Kohli, Tina Musuya, Sonia Rebecca Kusiima   +10 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Preemptive and Reactive Focus-on-Form Instruction: Effect on learning parallel grammatical structures

Revue des Sciences Humaines, 2016
The present study set out to investigate the differential effect of focus-on-form (FonF) instruction. Two research questions were raised: 1) Does FonF instruction,both preemptive and reactive, have a differential effect on learners' interlanguage?
Fouad BOULKROUN
doaj  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Evaluation the protective role of baicalin against H2O2-driven oxidation, inflammation and apoptosis in bovine mammary epithelial cells

Frontiers in Veterinary Science
Mastitis is one of the most common diseases in dairy farms. During the perinatal period, the bovine mammary epithelial cells (BMECs) of High-yielding dairy cows accelerate metabolism and produce large amounts of reactive oxygen species (ROS).
Xiaohui Kong, Mingyan Wang, Zhiheng Guo, Xingda Yang, Hongxia Lian, Tengyun Gao, Liyang Zhang, Tong Fu   +7 more
doaj   +1 more source

BREEDING AND UTILIZATION OF ARABIAN HORSE TODAY [PDF]

Poljoprivreda, 2000
Arab horse raising has a hundred year old tradition. A real stud farm raising started by purchasing original reproductive material from Asia in 1895, 1897 and 1899.
Vlasta Mandić, Josip Ljubešić, Tomo Rastija, Živko Bošnjak   +3 more
doaj  

Alternatives for Raising Living Standards [PDF]

Given the fundamental goal of raising living standards in the longer term, much attention is paid to policies that can be expected to increase national saving.
William Scarth
core  

LLS: Consciousness-Raising of the Latino/Communities Diversity [PDF]

, 2008
In Latinas/os everyday lives, their culture and their race are objectified and marginalized. Historically, this is represented in the assumption that Latin-American culture is ???Latino??? culture, when their experiences are in actuality quite different.
Galloway, Katelyn, Kattah, Maureen, N??????var, Daisy, Santillanes, Andy   +3 more
core